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Review Article | Open Access

Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner

Hui Maa, Yaozhong Hua, Bowei Zhanga, Zeping Shaob, Eugeni Rourab( ), Shuo Wanga( )
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China
Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD 4072, Australia

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

The metabolic syndrome (MS) has become one of the main problems in public health. Tea polyphenols (TPs), the main bioactive components of tea, has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the MS. However, many studies into the effects of TPs on MS have provided conflicting findings and the underlying mechanism has been elusive. The predominant TPs in unfermentedand and fermented tea are catechins and oxidized polyphenols (theaflavins and thearubigins), both of which have low bioavailability and reach the colon where most gut microbes inhabit. Gut microbiota has been demonstrated to be tightly associated with host metabolism. The interactions between TPs and gut microbiota will lead to the alterations of gut microbiota composition and the production of metabolites including short chain fatty acids, bile acids, amino acids and TPs derived metabolites, accordingly exerting their biological effects both locally and systemically. This review highlighted the contribution of metabolites and specific gut bacteria in the process of TPs intervention on the MS and further discuss how TPs impact the MS via gut microbiota from the viewpoint of gut organ/tissue axis.

Keywords

Gut microbiotaTea polyphenolsMetabolic syndromeMetabolitesGut organ/tissue axis

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Food Science and Human Wellness
Volume 11 Issue 1,
January 2022
Pages 11-21
DOI: 10.1016/j.fshw.2021.07.002
Cite this article:
Ma H, Hu Y, Zhang B, et al. Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner. Food Science and Human Wellness, 2022, 11(1): 11-21. https://doi.org/10.1016/j.fshw.2021.07.002

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Received: 25 September 2020
Revised: 21 October 2020
Accepted: 25 October 2020
Published: 11 September 2021
© 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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