AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Food Science and Human Wellness Article
PDF (440.2 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article | Open Access

Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes

Daoming Lia,b,c, Yang Zhud, Yonghua Wanga,c( ), Qiong Zoue, Jinzhu Duanf, Dongxiao Sun-Waterhousec, Baoguo Suna( )
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China
School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China
School of Food Science and Engineering, Guangdong Research Center of Lipid Science and Applied Engineering Technology, South China University of Technology, Guangzhou 510640, China
Bioprocess Engineering, Wageningen University and Research, 6700 AA Wageningen, Netherlands
Guangzhou Yong-h Special Nutrition Technology Co. Ltd, Guangzhou 510000, China
Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-DAGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients. This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism. To make a contribution to this field, this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs (ingested and endogenous) in the change of insulin sensitivity. Accordingly, strategies for further investigations on the metabolism of DAGs are proposed.

Keywords

LipidomicsDiacylglycerolsFunctional oilInsulin sensitivity

References

[1]

M.P. Czech, Insulin action and resistance in obesity and type 2 diabetes, Nat. Med. 23 (2017) 804-814. http://dx.doi.org/10.1038/nm.4350.
Crossref Google Scholar
[2]

S.E. Kahn, R.L. Hull, K.M. Utzschneider, Mechanisms linking obesity to insulin resistance and type 2 diabetes, Nature 444 (2006) 840-846. http://dx.doi.org/10.1038/nature05482.
Crossref Google Scholar
[3]

J. Li, J. Song, Y.Y. Zaytseva, et al., An obligatory role for neurotensin in high-fat-diet-induced obesity, Nature 533 (2016) 411-415. http://dx.doi.org/10.1038/nature17662.
Crossref Google Scholar
[4]

T. Nagao, H. Watanabe, N. Goto, et al., Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a doubleblind controlled trial, J. Nutr. 130 (2000) 792-797. http://dx.doi.org/10.1093/ jn/130.4.792.
Crossref Google Scholar
[5]

H. Kawashima, H. Takase, K. Yasunaga, et al., One-year ad libitum consumption of diacylglycerol oil as part of a regular diet results in modest weight loss in comparison with consumption of a triacylglycerol control oil in overweight Japanese subjects, J. Am. Diet. Assoc. 108 (2008) 57-66. http://dx.doi.org/10.1016/j.jada.2007.10.014.
Crossref Google Scholar
[6]

K. Tomonobu, T. Hase, I. Tokimitsu, Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol, Nutrition 22 (2006) 128-135. https://dx.doi. org/10.1016/j.nut.2005.04.016.
Crossref Google Scholar
[7]

T.C. Xu, X. Li, X.H. Ma, et al., Effect of diacylglycerol on postprandial serum triacylglycerol concentration: a meta-analysis, Lipids 44 (2009) 161- 168, https://dx.doi.org/10.1007/s11745-008-3258-2.
Crossref Google Scholar
[8]

S. Saito, T. Yamaguchi, K. Shoji, et al., Effect of low concentration of diacylglycerol on mildly postprandial hypertriglyceridemia, Atherosclerosis 213 (2010) 539-544. https://dx.doi.org/10.1016/ j.atherosclerosis.2010.07.062.
Crossref Google Scholar
[9]

K. Shoji, T. Mizuno, D. Shiiba, et al., Effects of a meal rich in 1,3-diacylglycerol on postprandial cardiovascular risk factors and the glucose-dependent insulinotropic polypeptide in subjects with high fasting triacylglycerol concentrations, J. Agr. Food Chem. 60 (2012) 2490-2496. https://dx.doi.org/10.1021/jf204825p.
Crossref Google Scholar
[10]

H. Takase, K. Shoji, T. Hase, et al., Effect of diacylglycerol on postprandial lipid metabolism in non-diabetic subjects with and without insulin resistance, Atherosclerosis 180 (2005) 197-204. https://dx.doi.org/10.1016/ j.atherosclerosis.2004.11.020.
Crossref Google Scholar
[11]

H. Yanai, H. Yoshida, Y. Tomono, et al., Effects of diacylglycerol on glucose, lipid metabolism, and plasma serotonin levels in lean Japanese, Obesity 16 (2008) 47-51. https://dx.doi.org/10.1038/oby.2007.46.
Crossref Google Scholar
[12]

J.S. Zheng, L. Wang, M. Lin, et al., BMI status influences the response of insulin sensitivity to diacylglycerol oil in Chinese type 2 diabetic patients, Asia. Pac. J. Clin. Nutr. 24 (2015) 65-72. https://dx.doi.org/10.6133/ apjcn.2015.24.1.01.
Crossref Google Scholar
[13]

S. Saito, A. Hernandez-Ono, H.N. Ginsberg, Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance, Metabolism 56 (2007) 1566-1575. https://dx.doi.org/10.1016/j.metabol.2007.06.024.
Crossref Google Scholar
[14]

T.K. Tang, B.K. Beh, N.B.M. Alitheen, et al., Suppression of visceral adipose tissue by palm kernel and soy-canola diacylglycerol in C57BL/6N mice, Eur. J. Lipid Sci. Tech. 115 (2013) 1266-1273. https://dx.doi. org/10.1002/ejlt.201300111.
Crossref Google Scholar
[15]

D. Li, T. Xu, H. Takase, et al., Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: a long-term randomized, double-blind controlled study, Clin. Nutr. 27 (2008) 203-211. https://dx.doi.org/10.1016/j.clnu.2008.01.009.
Crossref Google Scholar
[16]

R.J. Perry, L. Peng, G.W. Cline, et al., Mechanisms by which a very-lowcalorie diet reverses hyperglycemia in a rat model of type 2 diabetes, Cell Metab. 27 (2018) 210-217. https://dx.doi.org/10.1016/j.cmet.2017.10.004.
Crossref Google Scholar
[17]

M.C. Petersen, A.K. Madiraju, B.M. Gassaway, et al,. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance, J. Clin. Invest. 126 (2016) 4361-4371. https://dx.doi.org/10.1172/JCI86013.
Crossref Google Scholar
[18]

K.W. Ter Horst, P.W. Gilijamse, R.I. Versteeg, et al., Hepatic diacylglycerolassociated protein kinase cepsilon translocation links hepatic steatosis to hepatic insulin resistance in humans, Cell Rep. 19 (2017) 1997-2004. https://dx.doi.org/10.1016/j.celrep.2017.05.035.
Crossref Google Scholar
[19]

S.I. Itani, N.B. Ruderman, F. Schmieder, et al., Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha, Diabetes 51 (2002) 2005-2011. https://dx.doi.org/10.2337/diabetes.51.7.2005.
Crossref Google Scholar
[20]

V.T. Samuel, K.F. Petersen, G.I. Shulman, Lipid-induced insulin resistance: unravelling the mechanism, Lancet 375 (2010) 2267-2277. https://dx.doi.org/10.1016/S0140-6736(10)60408-4.
Crossref Google Scholar
[21]

G.I. Shulman, Cellular mechanisms of insulin resistance in humans, Am. J. Cardiol. 84 (1999) 3J-10J. https://dx.doi.org/10.1016/S0002-9149(99)00350-1.
Crossref Google Scholar
[22]

H. Tilg, A.R. Moschen, Adipocytokines: mediators linking adipose tissue, inflammation and immunity, Nat. Rev. Immunol. 6 (2006) 772-783. https://dx.doi.org/10.1038/nri1937.
Crossref Google Scholar
[23]

D.M. Erion, G.I. Shulman, Diacylglycerol-mediated insulin resistance, Nat. Med. 16 (2010) 400-402. https://dx.doi.org/10.1038/nm0410-400.
Crossref Google Scholar
[24]

J. Turinsky, D.M. O'Sullivan, B.P. Bayly, 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo, J. Biol. Chem. 265 (1990) 16880-16885. https://dx.doi.org/10.1111/j.1432-1033.1990.tb19336.x.
Crossref Google Scholar
[25]

F.R. Jornayvaz, A.L. Birkenfeld, M.J. Jurczak, et al., Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2, P. Natl. Acad. Sci. U.S.A. 108 (2011) 5748-5752. https://dx.doi.org/10.1073/pnas.1103451108.
Crossref Google Scholar
[26]

T. Jelenik, K. Kaul, G. Sequaris, et al., Mechanisms of insulin resistance in primary and secondary nonalcoholic fatty liver, Diabetes 66 (2017) 2241- 2253. https://dx.doi.org/10.2337/db16-1147.
Crossref Google Scholar
[27]

K. Lyu, Y. Zhang, D.Y. Zhang, et al., A membrane-bound diacylglycerol species induces PKCє-mediated hepatic insulin resistance, Cell Metab. 32 (2020) 654-664. https://dx.doi.org/10.1016/j.cmet.2020.08.001.
Crossref Google Scholar
[28]

N. Kumashiro, D.M. Erion, D.Y. Zhang, et al., Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease, P. Natl. Acad. Sci. U.S.A. 108 (2011) 16381-16385. https://dx.doi.org/10.1073/pnas.1113359108.
Crossref Google Scholar
[29]

L.T. Boni, R.R. Rando, The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols, J. Biol. Chem. 260 (1985) 10819-10825. https://dx.doi.org/10.1016/0165-022X(85)90070-3.
Crossref Google Scholar
[30]

R.R. Rando, N. Young, The stereospecific activation of protein kinase C, Biochem. Bioph. Res. Co. 122 (1984) 818-823. https://dx.doi.org/10.1016/ S0006-291X(84)80107-2.
Crossref Google Scholar
[31]

J. Szendroedi, T. Yoshimura, E. Phielix, et al., Role of diacylglycerol activation of PKCtheta in lipid-induced muscle insulin resistance in humans, P. Natl. Acad. Sci. U.S.A. 111 (2014) 9597-9602. https://dx.doi.org/10.1073/ pnas.1409229111.
Crossref Google Scholar
[32]

X. Qu, J.P. Seale, R. Donnelly, Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats-effects of feeding, J. Endocrinol. 162 (1999) 207-214. https://dx.doi.org/10.1002/hep.1840060621.
Crossref Google Scholar
[33]

B.C. Bergman, D.M. Hunerdosse, A. Kerege, et al., Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans, Diabetologia 55 (2012) 1140-1150. https://dx.doi.org/10.1007/ s00125-011-2419-7.
Crossref Google Scholar
[34]

M.C. Petersen, G.I. Shulman, Roles of diacylglycerols and ceramides in hepatic insulin resistance, Trends Pharmacol. Sci. 38 (2017) 649-665. https://dx.doi.org/10.1016/j.tips.2017.04.004.
Crossref Google Scholar
[35]

T.O. Eichmann, A. Lass, DAG tales: the multiple faces of diacylglycerolstereochemistry, metabolism, and signaling, Cell Mol. Life Sci. 72 (2015) 3931-3952. https://dx.doi.org/10.1007/s00018-015-1982-3.
Crossref Google Scholar
[36]

M.C. Petersen, G.I. Shulman, Mechanisms of insulin action and insulin resistance, Physiol. Rev. 98 (2018) 2133-2223. https://dx.doi.org/10.1152/ physrev.00063.2017.
Crossref Google Scholar
[37]

E. Montell, M. Turini, M. Marotta, et al., DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells, Am. J. Physiol. Endocrinol. Metab. 280 (2001) E229-E237. https://dx.doi.org/10.1016/S0167-0115(00)00187-7.
Crossref Google Scholar
[38]

J. Szendroedi, T. Yoshimura, E. Phielix, et al., Role of diacylglycerol activation of PKCtheta in lipid-induced muscle insulin resistance in humans, P. Natl. Acad. Sci. U.S.A. 111 (2014) 9597-9602. https://dx.doi.org/10.1073/ pnas.1409229111.
Crossref Google Scholar
[39]

A.M. Lundsgaard, K.A. Sjoberg, L.D. Hoeg, et al., Opposite regulation of insulin sensitivity by dietary lipid versus carbohydrate excess, Diabetes 66 (2017) 2583-2595. https://dx.doi.org/10.2337/db17-0046.
Crossref Google Scholar
[40]

B. Nowotny, L. Zahiragic, D. Krog, et al., Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans, Diabetes 62 (2013) 2240-2248. https://dx.doi.org/10.2337/db12-1179.
Crossref Google Scholar
[41]

A. Franko, D. Merkel, M. Kovarova, et al., Dissociation of fatty liver and insulin resistance in I148M PNPLA3 carriers: differences in diacylglycerol (DAG) FA18:1 lipid species as a possible explanation, Nutrients 10 (2018) 1314. https://dx.doi.org/10.3390/nu10091314.
Crossref Google Scholar
[42]

L. Perreault, S.A. Newsom, A. Strauss, et al., Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle, JCI Insight 3 (2018). https://dx.doi.org/10.1172/jci.insight.96805.
Crossref Google Scholar
[43]

K.T. Tonks, A.C. Coster, M.J. Christopher, et al., Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans, Obesity 24 (2016) 908-916. https://dx.doi.org/10.1002/oby.21448.
Crossref Google Scholar
[44]

E. Shmueli, K.G. Alberti, C.O. Record, Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance? J. Intern. Med. 234 (1993) 397-400. https://dx.doi.org/10.1111/j.1365-2796.1993.tb00761.x.
Crossref Google Scholar
[45]

S.U. Jayasinghe, A.T. Tankeu, F. Amati, Reassessing the role of diacylglycerols in insulin resistance, Trends Endocrin. Met. 30 (2019) 618-635. https://dx.doi.org/10.1016/j.tem.2019.06.005.
Crossref Google Scholar
[46]

R.C.R. Meex, M.J. Watt, Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance, Nat. Rev. Endocrinol. 13 (2017) 509-520. https://dx.doi.org/10.1038/nrendo.2017.56.
Crossref Google Scholar
[47]

R.J. Perry, J.G. Camporez, R. Kursawe, et al., Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes, Cell 160 (2015) 745-758. https://dx.doi.org/10.1016/j.cell.2015.01.012.
Crossref Google Scholar
[48]

V. Bezaire, A. Mairal, R. Anesia, et al., Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis, FEBS Lett. 583 (2009) 3045-3049. https://dx.doi.org/10.1016/j.febslet.2009.08.019.
Crossref Google Scholar
[49]

J. Laurencikiene, V. van Harmelen, E. Arvidsson Nordstrom, et al., NFkappaB is important for TNF-alpha-induced lipolysis in human adipocytes, J. Lipid Res. 48 (2007) 1069-1077. https://dx.doi.org/10.1194/jlr.M600471- JLR200.
Crossref Google Scholar
[50]

V.T. Samuel, G.I. Shulman, The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux, J. Clin. Invest. 126 (2016) 12-22. https://dx.doi.org/10.1172/JCI77812.
Crossref Google Scholar
[51]

K.F. Petersen, S. Dufour, D.B. Savage, et al., The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome, P. Natl. Acad. Sci. U.S.A. 104 (2007) 12587-12594. https://dx.doi.org/10.1073/ pnas.0705408104.
Crossref Google Scholar
[52]

H. Yanai, Y. Tomono, K. Ito, et al., Diacylglycerol oil for the metabolic syndrome, Nutr. J. 6 (2007) 43. https://dx.doi.org/10.1186/1475-2891-6-43.
Crossref Google Scholar
[53]

K. Yasunaga, S. Saito, Y.L. Zhang, et al., Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice, J. Lipid Res. 48 (2007) 1108-1121. https://dx.doi.org/10.1194/jlr.M600524-JLR200.
Crossref Google Scholar
[54]

M. Hu, F. Phan, O. Bourron, et al., Steatosis and NASH in type 2 diabetes, Biochimie 143 (2017) 37-41. https://dx.doi.org/10.1016/j.biochi.2017.10.019.
Crossref Google Scholar
[55]

B.L.A. Prabhavathi Devi, K.N. Gangadhar, R.B.N. Prasad, et al., Nutritionally enriched 1,3-diacylglycerol-rich oil: low calorie fat with hypolipidemic effects in rats, Food Chem. 248 (2018) 210-216. https://dx.doi.org/10.1016/j.foodchem.2017.12.066.
Crossref Google Scholar
[56]

S. Meguro, N. Osaki, N. Matsuo, et al., Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose-fed rats, Lipids 41 (2006) 347-355. https://dx.doi.org/10.1007/s11745-006-5105-7.
Crossref Google Scholar
[57]

B. Leibiger, T. Moede, M. Paschen, et al., PI3K-C2alpha knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation, Cell Rep. 13 (2015) 15-22. https://dx.doi.org/10.1016/j.celrep.2015.08.058.
Crossref Google Scholar
[58]

K. Yamamoto, H. Asakawa, K. Tokunaga, et al., Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type Ⅱ diabetic patients with hypertriglyceridemia, J. Nutr. 131 (2001) 3204-3207. https://dx.doi.org/10.1046/j.1365-277X.2001.00318.x.
Crossref Google Scholar
[59]

T.C. Xu, M. Jia, X. Li, et al., Intake of diacylglycerols and the fasting insulin and glucose concentrations: a meta-analysis of 5 randomized controlled studies, J. Am. Coll. Nutr. 37 (2018) 598-604. https://dx.doi.org/10.1080/073 15724.2018.1452168.
Crossref Google Scholar
[60]

T. Yanagita, I. Ikeda, Y.M. Wang, et al., Comparison of the lymphatic transport of radiolabeled 1,3-dioleoylglycerol and trioleoylglycerol in rats, Lipids 39 (2004) 827-832. https://dx.doi.org/10.1007/s11745-004-1303-6.
Crossref Google Scholar
[61]

A. McCullough, S. Previs, T. Kasumov, Stable isotope-based flux studies in nonalcoholic fatty liver disease, Pharmacol. Therapeut. 181 (2018) 22-33. https://dx.doi.org/10.1016/j.pharmthera.2017.07.008.
Crossref Google Scholar
[62]

C. Preuss, T. Jelenik, K. Bodis, et al., A new targeted lipidomics approach reveals lipid droplets in liver, muscle and heart as a repository for diacylglycerol and ceramide species in non-alcoholic fatty liver, Cells 8 (2019) 277. https://dx.doi.org/10.3390/cells8030277.
Crossref Google Scholar
[63]

K. Yang, X. Han, Lipidomics: techniques, applications, and outcomes related to biomedical sciences, Trends Biochem. Sci. 41 (2016) 954-969. https://dx.doi.org/10.1016/j.tibs.2016.08.010.
Crossref Google Scholar
Food Science and Human Wellness
Volume 11 Issue 2,
March 2022
Pages 230-237
DOI: 10.1016/j.fshw.2021.11.004
Cite this article:
Li D, Zhu Y, Wang Y, et al. Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes. Food Science and Human Wellness, 2022, 11(2): 230-237. https://doi.org/10.1016/j.fshw.2021.11.004

853

Views

57

Downloads

8

Crossref

7

Web of Science

8

Scopus

0

CSCD

Altmetrics
Received: 31 August 2020
Revised: 16 October 2020
Accepted: 25 October 2020
Published: 25 November 2021
© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return