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Research Article | Open Access

Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways

Huanmei Menga, Jia Songa( ), Bingqian Fana, Yingqi Lia, Jiaojiao Zhanga, Jinping Yub, Yu Zhenga, Min Wanga( )
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Tianjin Engineering Research Centre of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Shandong Engineering Research Centre of Condiment Fermentation Technology, Shandong Yutu Co., Ltd, Zibo 255300, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Monascus vinegar (MV) is a typical fermented food with various health-promoting effects. This study aimed to evaluate the role of MV in alleviating high-fat-diet-induced inflammation in rats with hyperlipidemia and elucidate the possible regulatory mechanisms. In the study, serum lipid profiles, liver pathology and liver inflammatory cytokines were analyzed in hyperlipidemia rats with MV (0.5 mL/kg mb, 2 mL/kg mb). Results showed that the administration of MV alleviated dyslipidemia by decreasing the serum and liver levels of triglyceride and total cholesterol. Increase in hepatic lipase and carnitine palmitoyl transferase 1 (CPT-1) levels and decrease in hepatocyte steatosis, nephritis, and intestinal tissue injury in the HD group showed that high-dose MV can significantly suppress hepatic lipid accumulation and steatosis. In addition, compared with the model (MOD) group, the HD group showed significantly down-regulated the level of serum or hepatic alanine aminotransferase (ALT), aspartate aminotransferase (AST), CPT-1, interleukin (IL)-2, IL-6, IL-12, and tumor necrosis factor α (TNF-α). Moreover, the HD group showed repressed hepatic nuclear factor κB (NF-κB) pathway and inactivated phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway mitigated liver inflammation. Similar results were obtained from cell experiments. Collectively, these findings revealed that MV might attenuate high-fat-diet-induced inflammation by inhibiting the NF-κB and PI3K/Akt/mTOR pathways.

Keywords

Monascus vinegarHyperlipidemiaInflammationNF-κBPI3K/AKT/mTOR

References

[1]

K. Oishi, T. Konishi, C. Hashimoto, et al., Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding, J. Nutr. Biochem. 52 (2018) 45-53. https://doi.org/10.1016/j.jnutbio.2017.09.024
Crossref Google Scholar
[2]

L. Tu, H. Sun, M. Tang, et al., Red raspberry extract (Rubus idaeus L. shrub) intake ameliorates hyperlipidemia in HFD-induced mice through PPAR signaling pathway, Food Chem. Toxicol. 133 110796 (2019). https://doi.org/10.1016/j.fct.2019.110796
Crossref Google Scholar
[3]

Y. Dong, H. Cheng, Y. Liu, et al., Red yeast rice ameliorates high-fat diet-induced atherosclerosis in: Apoe–/– mice in association with improved inflammation and altered gut microbiota composition, Food Funct. 10 (2019) 3880-3889. https://doi.org/10.1039/C9FO00583H
Crossref Google Scholar
[4]

E. Krauzová, J. Kračmerová, L. Rossmeislová, et al., Acute hyperlipidemia initiates proinflammatory and proatherogenic changes in circulation and adipose tissue in obese women, Atherosclerosis 250 (2016) 151-157. https://doi.org/10.1016/j.atherosclerosis.2016.04.021
Crossref Google Scholar
[5]

C. Liu, Y. Guo, L. Sun, et al., Six types of tea reduce high-fat-diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation, Food Funct. 10 (2019) 2061-2074. https://doi.org/10.1039/C8FO02334D
Crossref Google Scholar
[6]

M.Y. Selcuk, B. Aygen, A. Dogukan, et al., Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and streptozotocin-induced diabetic rats, Nutr. Metab. 9 (2012) 30. https://doi.org/10.1186/1743-7075-9-30
Crossref Google Scholar
[7]

J. Xiao, R. Zhang, Y. Wu, et al., Rice bran phenolic extract protects against alcoholic liver injury in mice by alleviating intestinal microbiota dysbiosis, barrier dysfunction, and liver inflammation mediated by the endotoxin-TLR4-NF-κB pathway, J. Agric. Food Chem. 68 (2020) 1237-1247. https://doi.org/10.1021/acs.jafc.9b04961
Crossref Google Scholar
[8]

B. Li, Z. Cheng, X. Sun, et al., Lonicera caerulea L. polyphenols alleviate oxidative stress-induced intestinal environment imbalance and lipopolysaccharide-induced liver injury in HFD-Fed rats by regulating the Nrf2/HO-1/NQO1 and MAPK pathways, Mol. Nutr. Food Res. 64(10) (2020) 190315. https://doi.org/10.1002/mnfr.201901315
Crossref Google Scholar
[9]

C. Ma, W. Ma, Plantamajoside inhibits lipopolysaccharide-induced MUC5AC expression and inflammation through suppressing the PI3K/Akt and NF-κB signaling pathways in human airway epithelial cells, Inflammation 41 (2018) 795-802. https://doi.org/10.1007/s10753-018-0733-7
Crossref Google Scholar
[10]

L.P. Sousa, A.F. Carmo, B.M. Rezende, et al., Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-κB, Biochem. Pharmacol. 78 (2009) 396-405. https://doi.org/10.1016/j.bcp.2009.04.030
Crossref Google Scholar
[11]

R. Kumar, S. Grover, V.K. Batish, Hypocholesterolaemic effect of dietary inclusion of two putative probiotic bile salt hydrolase-producing Lactobacillus plantarum strains in Sprague-Dawley rats, Br. J. Nutr. 105 (2011) 561-573. https://doi.org/10.1017/S0007114510003740
Crossref Google Scholar
[12]

W. Zhou, R. Guo, W. Guo, et al., Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet, Food Funct. 10 (2019) 1073-1084. https://doi.org/10.1039/C8FO02192A
Crossref Google Scholar
[13]

W. Zhu, Y. Liu, X. Duan, et al., Alteration of the gut microbiota by vinegar is associated with amelioration of hyperoxaluria-induced kidney injury, Food Funct. 11 (2020) 2639-2653. https://doi.org/10.1039/C9FO02172H
Crossref Google Scholar
[14]

N.E. Mohamad, S.K. Yeap, H. Ky, et al., Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice, Food Nutr. Res. 61 (2017) 1368322. https://doi.org/10.1080/16546628.2017.1368322
Crossref Google Scholar
[15]

M.E. Liu, C.H. Chou, L. Li, et al., Modulation effects of black-vinegar-based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects, J. Sci. Food Agric. 100 (2020) 2380-2388. https://doi.org/10.1002/jsfa.10246
Crossref Google Scholar
[16]

Y. Zheng, K. Liu, W. Yan, et al., Amino acid, mineral, and degree of hydrolysis of vinegar-egg and its lipid lowering and antioxidant effects in vitro and in vivo, Sains Malaysiana 48 (2019) 1643-1654. http://doi.org/10.17576/jsm-2019-4808-10
Crossref Google Scholar
[17]

G. He, M. Karin, NF-κB and STAT3-key players in liver inflammation and cancer, Cell Res. 21 (2011) 159-168. https://doi.org/10.1038/cr.2010.183
Crossref Google Scholar
[18]

J.I. Odegaard, A. Chawla, The immune system as a sensor of the metabolic state, Immunity 38 (2013) 644-654. https://doi.org/10.1016/j.immuni.2013.04.001
Crossref Google Scholar
[19]

F. Affuso, A. Ruvolo, F. Micillo, et al., Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study, Nutr. Metab. Cardiovasc. Dis. 20 (2010) 656-661. https://doi.org/10.1016/j.numecd.2009.05.017
Crossref Google Scholar
[20]

A. Bouazza, A. Bitam, M. Amiali, et al., Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats, Pharm. Biol. 54 (2016) 260-265. https://doi.org/10.3109/13880209.2015.1031910
Crossref Google Scholar
[21]

H. Zhou, X.M. Li, J. Meinkoth, et al., Akt regulates cell survival and apoptosis at a postmitochondrial level, J. Cell Biol. 151 (2000) 483-494. https://doi.org/10.1083/jcb.151.3.483
Crossref Google Scholar
[22]

L. Zhang, T. Zhang, L. Ding, et al., The protective activities of dietary sea cucumber cerebrosides against atherosclerosis through regulating inflammation and cholesterol metabolism in male mice, Mol. Nutr. Food 62 (2018) 1-10. https://doi.org/10.1002/mnfr.201800315
Crossref Google Scholar
[23]

L. Ding, T. Zhang, H. Che, et al., Saponins of sea cucumber attenuate atherosclerosis in ApoE−/− mice via lipid-lowering and anti-inflammatory properties, J. Funct. Foods 48 (2018) 490-497. https://doi.org/10.1016/j.jff.2018.07.046
Crossref Google Scholar
[24]

J. Razmi, G. Jelodar, H. Ebrahimi, et al., Effect of Aegle marmelos Fruit juice concentrate on serum glucose and lipid level and ALT/AST activities in diabetic rats, J. Kerman Univ. Med. Sci. 13(4) (2014) 240-245
Google Scholar
[25]

B.K. Beh, N.E. Mohamad, S.K. Yeap, et al., Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice. Sci. Rep. 7 (2017) 6664. https://doi.org/10.1038/s41598-017-06235-7
Crossref Google Scholar
[26]

D. Feng, J. Zou, D. Su, et al., Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation, Nutr. Metab. 16 (2019) 79. https://doi.org/10.1186/s12986-019-0410-3
Crossref Google Scholar
[27]

H. Kim, H. Lee, K.S. Shin, Intestinal immunostimulatory activity of neutral polysaccharide isolated from traditionally fermented Korean brown rice vinegar, Biosci. Biotechnol. Biochem. 80 (2016) 2383-2390. https://doi.org/10.1080/09168451.2016.1217149
Crossref Google Scholar
[28]

A.T. Hamed, R.A. Matar, The effect of apple cider vinegar and grape vinegar on lipid profile in albino white rats, Jordan J. Pharm. Sci. 7 (2014) 163-170
Crossref Google Scholar
[29]

H. Chang, X. Li, Q. Cai, et al., The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells, Int. J. Mol. Med. 40 (2017) 182-192. https://doi.org/10.3892/ijmm.2017.3008
Crossref Google Scholar
[30]

F. Han, Q.Q. Xiao, S. Peng, et al., Atorvastatin ameliorates LPS-induced inflammatory response by autophagy via AKT/mTOR signaling pathway, J. Cell. Biochem. 119 (2018) 1604-1615. https://doi.org/10.1002/jcb.26320
Crossref Google Scholar
[31]

K. Chen, P. Iribarren, W. Gong, et al., The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer, Cell. Mol. Immunol. 2 (2005) 241-252
Google Scholar
[32]

H. Takahashi, H. Chi, S. Mohri, et al., Correction to rice koji extract enhances lipid metabolism through peroxisome proliferator-activated receptor alpha (PPARα) activation in mouse liver, J. Agric. Food Chem. 65 (2017) 251. https://doi.org/10.1021/acs.jafc.6b05717
Crossref Google Scholar
[33]

M. Cargnello, J. Tcherkezian, P.P. Roux, The expanding role of mTOR in cancer cell growth and proliferation, Mutagenesis 30 (2015) 169-176. https://doi.org/10.1093/mutage/geu045
Crossref Google Scholar
[34]

A. Tapia-Abellán, A.J. Ruiz-Alcaraz, T. Hernández-Caselles, et al., Role of MAP kinases and PI3K-Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patients, Liver Int. 33 (2013) 552-560. https://doi.org/10.1111/liv.12072
Crossref Google Scholar
[35]

C. Chen, X. Han, P. Ding, et al., Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice, Food Funct. 9 (2018) 861-870. https://doi.org/10.1039/c7fo01599b
Crossref Google Scholar
[36]

H. Zhang, C. Chen, L. Ding, et al., Sea cucumbers-derived sterol sulfate alleviates insulin resistance and inflammation in high-fat-high-fructose diet-induced obese mice, Pharmacol. Res. 160 (2020) 105191. https://doi.org/10.1016/j.phrs.2020.105191
Crossref Google Scholar
Food Science and Human Wellness
Volume 11 Issue 4,
July 2022
Pages 943-953
DOI: 10.1016/j.fshw.2022.03.024
Cite this article:
Meng H, Song J, Fan B, et al. Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways. Food Science and Human Wellness, 2022, 11(4): 943-953. https://doi.org/10.1016/j.fshw.2022.03.024

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Received: 23 September 2020
Revised: 17 November 2021
Accepted: 16 December 2020
Published: 28 April 2022
© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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