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Research Article | Open Access

Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings

Rong Lia,1, Songzuo Yub,1, Xiao Lianga, Yu Lia, Keng Po Laia( )
Laboratory of Environmental Pollution and Integrative Omics, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, China
Department of Neurosurgery, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, China

1 They contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Background

Epidemiological data indicate an association between cadmium exposure and risk of bone fracture; however, clinical treatment of cadmium-induced fracture is limited. Although vitamin C (VC) reportedly reduces cadmium-induced fracture, its pharmacological mechanism remains unexplored.

Methods

Thus, we used a network pharmacology approach and molecular docking analysis to identify core targets, functional processes, and biological pathways involved in the anti-fracture action of VC.

Results

Bioinformatics identified 17 intersection targets of VC and cadmium-induced fracture. Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. Interestingly, findings of molecular docking analysis indicated that VC exerted effective binding capacity in cadmium-induced fracture. Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized.

Conclusions

Based on these findings, we conclude that VC exhibits its anti-cadmium-induced fracture effects by promoting osteoblastic regeneration and proliferation, and inhibiting inflammatory stress. The core targets may serve as biomarkers for diagnosing cadmium-induced fractures.

Keywords

MechanismCadmiumFractureNetwork pharmacologyVitamin C

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Food Science and Human Wellness
Volume 11 Issue 5,
September 2022
Pages 1384-1391
DOI: 10.1016/j.fshw.2022.04.026
Cite this article:
Li R, Yu S, Liang X, et al. Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings. Food Science and Human Wellness, 2022, 11(5): 1384-1391. https://doi.org/10.1016/j.fshw.2022.04.026

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Received: 23 December 2020
Revised: 09 January 2021
Accepted: 18 January 2021
Published: 02 June 2022
© 2022 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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