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Research Article | Open Access

Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

Chao Tanga,1, Weiwei Zhoua,1, Mengyuan Shana, Zhaoxin Lua( ), Yingjian Lub( )
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China

1 The co-fi rst author

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosis in high-fat diet (HFD)-fed mice. Results showed that oral administration of L. plantarum Q16 improved serum and hepatic lipid profile. Protein analysis showed that L. plantarum Q16 could reduce hepatic lipid content by reducing the expression of FAS, ACC, SCD-1, Srebp-1c and ATGL, but increasing expression levels of CPT-1α, PPAR-α and ATGL. Meanwhile, L. plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1α signaling pathway. Metagenomic analysis also discovered that L. plantarum Q16 increased species diversity and richness of intestinal microbiota, promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice. Overall, L. plantarum Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.

Keywords

Energy metabolismLipid metabolismLactobacillus plantarum Q16Non-alcoholic fatty acid liver diseaseColonic microbiota

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Food Science and Human Wellness
Volume 11 Issue 5,
September 2022
Pages 1428-1439
DOI: 10.1016/j.fshw.2022.04.034
Cite this article:
Tang C, Zhou W, Shan M, et al. Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice. Food Science and Human Wellness, 2022, 11(5): 1428-1439. https://doi.org/10.1016/j.fshw.2022.04.034

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Received: 22 September 2021
Revised: 12 October 2021
Accepted: 28 November 2021
Published: 02 June 2022
© 2022 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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