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Research Article | Open Access

4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions

Sujin Parka,1, YoonA Kima,1, Jaewang Leea, Hyunsoo Seoa, Sang-Jip Namb, Dong-Gyu Joc, Dong-Hoon Hyuna( )
Department of Life Science, Ewha Womans University, Seoul 03760, South Korea
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, South Korea
School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea

1 These authors contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Many approaches to neurodegenerative diseases that focus on amyloid-β clearance and gene therapy have not been successful. Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. Plasma membrane (PM) redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial dysfunction. Neurohormetic phytochemicals are known to induce the expression of detoxifying enzymes under stress conditions. In this study, mechanisms of neuroprotective effects of 4-hydroxycinnamic acid (HCA) were examined by analyzing cell survival, levels of abnormal proteins, and mitochondrial functions in two different neuronal cells. HCA protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD+/NADH ratio. Cells cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the mitochondria. HCA increased the mitochondrial complexes I and II activities and ATP production. Also, HCA increased mitochondrial fusion and decreased mitochondrial fission. Overall, HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress conditions. These findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

Keywords

NeuroprotectionNADH-quinone oxidoreductase 1 (NQO1)Cytochrome b5 reductase4-Hydroxycinnamic acidImproved mitochondrial functions

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Food Science and Human Wellness
Volume 12 Issue 4,
July 2023
Pages 1287-1299
DOI: 10.1016/j.fshw.2022.10.011
Cite this article:
Park S, Kim Y, Lee J, et al. 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions. Food Science and Human Wellness, 2023, 12(4): 1287-1299. https://doi.org/10.1016/j.fshw.2022.10.011

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Received: 03 February 2022
Revised: 24 March 2022
Accepted: 07 May 2022
Published: 18 November 2022
© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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