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Research Article | Open Access

Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice

Aimei Liaoa,b,1, Xing Lyua,c,1, Jiarui Maa, Yinchen Houb, Ming Huia, Na Liua, Yi Zhaoa, Yixiang Cuia, Jihong Huanga,b,d( )
College of Biological Engineering, Henan University of Technology, Luoyang 471000, China
Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Luoyang 471000, China
Zhengzhou Synear Food Co., Ltd., Zhengzhou 450000, China
School of Food and Pharmacy, Xuchang University, Xuchang 461000, China

1 These authors equally contributed to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Wheat embryo globulin (WEG) has been proven to possess multiple biological activities, including antioxidative properties, immunomodulatory, and so on. Aged mouse model were established by subcutaneous injection of D-galactose (D-gal), and the effects of WEG on learning, memory, and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination. Compared with the Model group, WEG improved the percentage of the platform quadrant, increased the number of crossing platforms, and enhanced the identification indexs. WEG also increased total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in the liver and brains of aging mice, and reduced malondialdehyde (MDA) content. Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice. These results effectively revealed that WEG not only improved the abilities of learning and memory, and the cognitive impairment, but also delayed the aging process of the D-gal-induced mice.

Keywords

Antioxidant activitySuperoxide dismutaseWheat embryo globulinD-galactoseGlutathione peroxidase

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Food Science and Human Wellness
Volume 12 Issue 4,
July 2023
Pages 1300-1308
DOI: 10.1016/j.fshw.2022.10.012
Cite this article:
Liao A, Lyu X, Ma J, et al. Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice. Food Science and Human Wellness, 2023, 12(4): 1300-1308. https://doi.org/10.1016/j.fshw.2022.10.012

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Received: 07 May 2021
Revised: 04 September 2021
Accepted: 26 October 2021
Published: 18 November 2022
© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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