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Review Article | Open Access

Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents

Weiyi Chua, Chia Wei Phana,b,c( ), Seng Joe Limd,e, Abdul Salam Babjid,e
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Clinical Investigation Centre, University Malaya Medical Centre, Lembah Pantai Kuala Lumpur 59100, Malaysia
Mushroom Research Centre, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, Malaysia
Innovation Centre for Confectionery Technology (MANIS), Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, Malaysia

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird's nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models. Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides. Bioactive compounds in EBN, especially sialic acid, add value to neurotrophic potential of EBN and contribute to neuronal repair and protection. Various studies reporting the neuroprotective effects of EBN, their molecular mechanisms, and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.

Keywords

AntioxidantNeurodegenerative diseaseCompositionNeuroprotectionEdible bird nestSialylated mucin glycopeptide

References

[1]

V.L. Feigin, E. Nichols, T. Alam, et al., Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the global burden of disease study 2016, Lancet Neurol. 18 (2019) 459-480. https://doi.org/10.1016/S1474-4422(18)30499-X
Crossref Google Scholar
[2]
World Health Organization, Global action plan on the public health response to dementia 2017 - 2025.
[3]
United Nations Department of Economic and Social Affairs, Population Division, World Population Ageing 2019: Highlights, (2019).
[4]

R.M. Liu, Aging, cellular senescence, and Alzheimer's disease, Int. J. Mol. Sci. 23 (2020) 1989. https://doi.org/10.3390/ijms23041989.
Crossref Google Scholar
[5]

V. Kluever, E.F. Fornasiero, Principles of brain aging: status and challenges of modeling human molecular changes in mice, Ageing Res. Rev. 72 (2021) 101465. https://doi.org/10.1016/j.arr.2021.101465.
Crossref Google Scholar
[6]

S.V. Helena, R.A. Selva, Effect of chronic oxidative stress on neuroinflammatory response mediated by CD4(+)T cells in neurodegenerative diseases, Front. Cell. Neurosci. 12 (2018) 114. https://doi.org/10.3389/fncel.2018.00114.
Crossref Google Scholar
[7]

Y. Tang, W. Le, Differential roles of M1 and M2 microglia in neurodegenerative diseases, Mol. Neurobiol. 53 (2015) 1181-1194. https://doi.org/10.1007/s12035-014-9070-5.
Crossref Google Scholar
[8]

D. Martirosyan, J. Singh, A new definition of functional food by FFC: what makes a new definition unique? Func. Foods Health Dis. 5 (2015) 209-223.
Crossref Google Scholar
[9]

G. Li, T.H. Lee, G. Chan, K.W.K. Tsim, Editorial: edible bird's nest—chemical composition and potential health efficacy and risks, Front. Pharmacol. 12 (2022) 819461. https://doi.org/10.3389/fphar.2021.819461.
Crossref Google Scholar
[10]

K.C. Chok, M.G. Ng, K.Y. Ng, et al., Edible bird's nest: recent updates and industry insights based on laboratory findings, Front. Pharmacol. 12 (2021) 746656. https://doi.org/10.3389/fphar.2021.746656.
Crossref Google Scholar
[11]

S.M. Chye, S.K. Tai, R.Y. Koh, et al., A mini review on medicinal effects of edible bird's nest, Lett. Health Biol. Sci. 2 (2017) 1-3. https://doi.org/10.15436/2475-6245.17.016.
Crossref Google Scholar
[12]

S.S. Teh, Z.F. Ma, Bioactive components and pharmacological properties of edible bird's nest, Int. Proc. Chem. Biol. Environ. Eng. 103 (2018) 29-34. https://doi.org/10.7763/IPCBEE.2018.V103.7.
Crossref Google Scholar
[13]

H.S.M. Noor, A. Babji, S.J. Lim, Nutritional composition of different grades of edible bird's nest and its enzymatic hydrolysis, The 2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium, 1940 (2018) 020088.
Crossref Google Scholar
[14]

A. Ling, L.S. Chang, A.S. Babji, et al., Review of sialic acid's biochemistry, sources, extraction and functions with special reference to edible bird's nest, Food Chem. 367 (2022) 130755. https://doi.org/10.1016/j.foodchem.2021.130755.
Crossref Google Scholar
[15]

H. Goshtasbi, P.S. Pakchin, A. Movafeghi, et al., Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease, Neurochem. Int. 153 (2022) 105268. https://doi.org/10.1016/j.neuint.2021.105268.
Crossref Google Scholar
[16]

Z. Liu, T. Zhou, A.C. Ziegler, et al., Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications, Oxid. Med. Cell. Longev. 2017 (2017) 2525967. https://doi.org/10.1155/2017/2525967.
Crossref Google Scholar
[17]

A. Melo, L. Monteiro, R.M.F. Lima, et al., Oxidat ive stress in neurodegenerative diseases: mechanisms and therapeutic perspect ives, Oxid. Med. Cel l. Longev. 2011 (2011) 467180. https://doi.org/10.1155/2011/467180.
Crossref Google Scholar
[18]

G.H. Kim, J.E. Kim, S.J. Rhie, et al., The role of oxidative stress in neurodegenerative diseases, Exp. Neurobiol. 24 (2015) 325-340. https://doi.org/10.5607/en.2015.24.4.325.
Crossref Google Scholar
[19]

R. Stefanatos, A. Sanz, The role of mitochondrial ROS in the aging brain, FEBS Letters. 592 (2018) 743-758. https://doi.org/10.1002/1873-3468.12902.
Crossref Google Scholar
[20]

J. Blesa, I. Trigo-Damas, A. Quiroga-Varela, et al., Oxidative stress and Parkinson's disease, Front. Neuroanat. 9 (2015) 91. https://doi.org/10.3389/fnana.2015.00091.
Crossref Google Scholar
[21]

R. Sultana, M. Perluigi, D.A. Butterfield, Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain, Free Rad. Biol. Med. 62 (2013) 157-169. https://doi.org/10.1016/j.freeradbiomed.2012.09.027.
Crossref Google Scholar
[22]

A. Ayala, M.F. Muñoz, S. Argüelles, Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal, Oxid. Med. Cell. Longev. 2014 (2014) 360438. https://doi.org/10.1155/2014/360438.
Crossref Google Scholar
[23]

M. Shichiri, The role of lipid peroxidation in neurological disorders, J. Clin. Biochem. Nutr. 54 (2014) 151-160. https://doi.org/10.3164/jcbn.14-10.
Crossref Google Scholar
[24]

Z. Hou, M.U. Imam, M. Ismail, et al., Lactoferrin and ovotransferrin contribute toward antioxidative effects of edible bird's nest against hydrogen peroxide-induced oxidative stress in human SH-SY5Y cells, Biosci. Biotechnol. Biochem. 79 (2015) 1570-1578. https://doi.org/10.1080/091684 51.2015.1050989.
Crossref Google Scholar
[25]

F. Blandini, O. Brustle, N. Deglon, et al., Experimental models for neurodegenerative diseases, Report of the Neurodegenerative Disorders Research Action Group (2014) 1-44.
Google Scholar
[26]

S. Franceschelli, P. Lanuti, A. Ferrone, et al., Modulation of apoptotic cell death and neuroprotective effects of glutathione—L-dopa codrug against H2O2-induced cellular toxicity, Antioxidants 8 (2019) 319. https://doi.org/10.3390/antiox8080319.
Crossref Google Scholar
[27]

M.Y. Yew, R.Y. Koh, S.M. Chye, et al., Edible bird's nest improves motor behavior and protects dopaminergic neuron against oxidative and nitrosative stress in Parkinson's disease mouse model, J. Funct. Foods 48 (2018) 576-585. https://doi.org/10.1016/j.jff.2018.07.058.
Crossref Google Scholar
[28]

J.H.T. Power, P.C. Blumbergs, Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies, Acta Neuropathol. 117 (2009) 63-73. https://doi.org/10.1007/s00401-008-0438-3.
Crossref Google Scholar
[29]

Z. Hou, M.U. Imam, M. Ismail, et al., Effects of edible bird's nest on hippocampal and cortical neurodegeneration in ovariectomized rats, Food Funct. 6 (2015) 1701-1711. https://doi.org/10.1039/c5fo00226e.
Crossref Google Scholar
[30]

S. Zárate, T. Stevnsner, R. Gredilla, Role of estrogen and other sex hormones in brain aging. neuroprotection and DNA repair, Front. Aging Neurosci. 9 (2017) 430. https://doi.org/10.3389/fnagi.2017.00430.
Crossref Google Scholar
[31]

Y.H. Huang, Q.H. Zhang, Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress, Brit. J Nutr. 104 (2010) 1297-1303. https://doi.org/10.1017/S0007114510002291.
Crossref Google Scholar
[32]
C.C.C. Mendoza, C.A.J. Zamarripa, Menopause induces oxidative stress in: J. A. Morales-González (Eds.), Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants, 2013.
[33]

R.A. Ismaeil, C.K. Hui, K.A. Affandi, et al., Neuroprotective effect of edible bird's nest in chronic cerebral hypoperfusion induced neurodegeneration in rats, Neuroimmunol. Neuroinflamm. 8 (2021) 63. http://dx.doi.org/10.20517/2347-8659.2020.63.
Crossref Google Scholar
[34]
M. Chandra, M. Panchatcharam, S. Miriyala, Biomarkers in ROS and role of isoprostanes in oxidative stress in: A. Rizwan (Eds.), Free Radicals and Diseases, IntechOpen, 2016.
Crossref
[35]

K. Nowotny, T. Jung, A. Höhn, et al., Advanced glycation end products and oxidative stress in type 2 diabetes mellitus, Biomolecules 5 (2015) 194-222. https://doi.org/10.3390/biom5010194.
Crossref Google Scholar
[36]

Y. Xing, X. Zhang, X. Song, et al., Injury of cortical neurons is caused by the advanced glycation end products-mediated pathway, Neural Regen. Res. 8 (2013) 909-915. https://doi.org/10.3969/j.issn.1673-5374.2013.10.005.
Crossref Google Scholar
[37]

Z. Hou, P. He, M.U. Imam, et al., Edible bird's nest prevents menopause-related memory and cognitive decline in rats via increased hippocampal sirtuin-1 expression, Oxidative Med. Cell. Longev. 2017 (2017) 7205082. https://doi.org/10.1155/2017/7205082.
Crossref Google Scholar
[38]

Y. Xie, H. Zeng, Z. Huang, et al., Effect of maternal administration of edible bird ' s nest on the learning and memory abilities of suckling offspring in mice, Neural Plastic. 2018 (2018) 7697261. https://doi.org/10.1155/2018/7697261.
Crossref Google Scholar
[39]

B. Wang, Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition, Adv. Nutr. 3 (2012) 465S-472S. https://doi.org/10.3945/an.112.001875.
Crossref Google Scholar
[40]

I. Yang, S.J. Han, G. Kaur, et al., The role of microglia in central nervous system immunity and glioma immunology, J. Clin. Neurosci. 17 (2010) 6-10. https://doi.org/10.1016/j.jocn.2009.05.006.
Crossref Google Scholar
[41]

L. Carniglia, D. Ramírez, D. Durand, et al., Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases, Mediat. Inflamm. 2017 (2017) 5048616. https://doi.org/10.1155/2017/5048616.
Crossref Google Scholar
[42]

C.S. Subhramanyam, C. Wang, Q. Hu, et al., Microglia-mediated neuroinflammation in neurodegenerative diseases, Semin. Cell Dev. Biol. 94 (2019) 112-120. https://doi.org/10.1016/j.semcdb.2019.05.004.
Crossref Google Scholar
[43]

T. Chitnis, H.L. Weiner, CNS inflammation and neurodegeneration, J. Clin. Neurosci. 127 (2017) 3577-3587. https://doi.org/10.1172/JCI90609.
Crossref Google Scholar
[44]

A. Roy, A. Jana, K. Yatish, et al., Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: implications for neurodegenerative diseases, Free Rad. Biol. Med. 45 (2008) 686-699. https://doi.org/10.1016/j.freeradbiomed.2008.05.026.
Crossref Google Scholar
[45]

S. Careena, D. Sani, S.N. Tan, et al., Effect of edible bird's nest extract on lipopolysaccharide-induced impairment of learning and memory in Wistar rats, Evid. Based Complement. Alternat. Med. 2018 (2018) 9318789. https://doi.org/10.1155/2018/9318789.
Crossref Google Scholar
[46]

C.R.A. Batista, G.F. Gomes, E. Candelario-Jalil, et al., Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration, Int. J. Mol. Sci. 20 (2019) 2293. https://doi.org/10.3390/ijms20092293.
Crossref Google Scholar
[47]

Z. Yida, M.U. Imam, M. Ismail, et al., Edible bird's nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes, BMC Complement. Altern. Med. 15 (2015) 310. https://doi.org/10.1186/s12906-015-0843-9.
Crossref Google Scholar
[48]

A. Haghani, P. Mehrbod, N. Safi, et al., In vitro and in vivo mechanism of immunomodulatory and antiviral activity of Edible bird's nest (EBN) against influenza A virus (IAV) infection, J. Ethnopharmacol. 185 (2016) 327-340. https://doi.org/10.1016/j.jep.2016.03.020.
Crossref Google Scholar
[49]

J.-M. Zhang, J. An, Cytokines, inflammation, and pain, Int. Anesthesiol. Clin. 45 (2007) 27-37. https://doi.org/10.1097/AIA.0b013e318034194e.
Crossref Google Scholar
[50]

K. Byun, Y. Yoo, M. Son, et al., Advanced glycation end-products produced systemically and by macrophages: a common contributor to inflammation and degenerative diseases, Pharmacol. Ther. 177 (2017) 44-55. https://doi.org/10.1016/j.pharmthera.2017.02.030.
Crossref Google Scholar
[51]

A. Villa, E. Vegeto, A. Poletti, et al., Estrogens, neuroinflammation, and neurodegeneration, Endocr. Rev. 37 (2016) 372-402. https://doi.org/10.1210/er.2016-1007.
Crossref Google Scholar
[52]

M. Liu, L. Qin, L. Wang, et al., α-synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum-Golgi compartment, Mol. Med. Rep. 18 (2018) 322-332. https://doi.org/10.3892/mmr.2018.9002.
Crossref Google Scholar
[53]

H. Chi, H.Y. Chang, T.K. Sang, Neuronal cell death mechanisms in major neurodegenerative diseases, Int. J. Mol. Sci. 19 (2018) 3082. https://doi.org/10.3390/ijms19103082.
Crossref Google Scholar
[54]

D.E. Bredesen, Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence, Mol. Neurodegener. 4 (2009) 27. https://doi.org/10.1186/1750-1326-4-27.
Crossref Google Scholar
[55]

S. Ghavami, S. Shojaei, B. Yeganeh, et al., Autophagy and apoptosis dysfunction in neurodegenerative disorders, Prog. Neurobiol. 112 (2014) 24-49. https://doi.org/10.1016/j.pneurobio.2013.10.004.
Crossref Google Scholar
[56]

M.Y. Yew, R.Y. Koh, S.M. Chye, et al., Edible bird's nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells, BMC Complement. Altern. Med. 14 (2014) 391. https://doi.org/10.1186/1472-6882-14-391.
Crossref Google Scholar
[57]

G.V. Chaitanya, A.J. Steven, P.P. Babu, PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration, Cell Commun. Signal. 8 (2010) 31. https://doi.org/10.1186/1478-811X-8-31.
Crossref Google Scholar
[58]

H.L. Ko, E.C. Ren, Functional aspects of PARP1 in DNA repair and transcription, Biomolecules 2 (2012) 524-548. https://doi.org/10.3390/biom2040524.
Crossref Google Scholar
[59]

G. Verdile, S.E. Gandy, R.N. Martins, The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid, Neurochem. Res. 32 (2007) 609-623. https://doi.org/10.1007/s11064-006-9131-x.
Crossref Google Scholar
[60]

Y.J. Chang, N.H. Linh, Y.H. Shih, et al., Alzheimer's amyloid-β sequesters caspase-3 in vitro via its C-terminal tail, ACS Chemical Neuroscience. 7 (2016) 1097-1106. https://doi.org/10.1021/acschemneuro.6b00049.
Crossref Google Scholar
[61]

Y. Tsujimoto, T. Nakagawa, S. Shimizu, Mitochondrial membrane permeability transition and cell death, Biochim. Biophys. Acta Bioenerg. 1757 (2006) 1297-1300. https://doi.org/10.1016/j.bbabio.2006.03.017.
Crossref Google Scholar
[62]

I.H. Witte, Sven, Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells, Meth. Enzymol. 489 (2011) 127-146. https://doi.org/10.1016/B978-0-12-385116-1.00008-X.
Crossref Google Scholar
[63]

C.V. Vorhees, M.T. Williams, Assessing spatial learning and memory in rodents, ILAR J. 55 (2014) 310-332. https://doi.org/10.1093/ilar/ilu013.
Crossref Google Scholar
[64]

K.S. Anand, V. Dhikav, Hippocampus in health and disease: an overview, Ann. Indian Acad. Neurol. 15 (2012) 239-246. https://doi.org/10.4103/0972-2327.104323.
Crossref Google Scholar
[65]

D.M.C. Torres, F.P. Cardenas, Synaptic plasticity in Alzheimer's disease and healthy aging, Rev. Neurosci. 31 (2020) 245-268. https://doi.org/10.1515/revneuro-2019-0058.
Crossref Google Scholar
[66]

S. Weinmann, S. Roll, C. Schwarzbach, et al., Effects of Ginkgo biloba in dementia: systematic review and meta-analysis, BMC Geriatr. 10 (2010) 14. https://doi.org/10.1186/1471-2318-10-14.
Crossref Google Scholar
[67]

O. Mahaq, M.A. P Rameli, M. Jaoi Edward, et al., The effects of dietary edible bird nest supplementation on learning and memory functions of multigenerational mice, Brain Behav. 10 (2020) e01817. https://doi.org/10.1002/brb3.1817.
Crossref Google Scholar
[68]

S. Michán, Y. Li, M.M.H. Chou, et al., SIRT1 is essential for normal cognitive function and synaptic plasticity, J. Neurosci. 30 (2010) 9695-9707. https://doi.org/10.1523/JNEUROSCI.0027-10.2010.
Crossref Google Scholar
[69]

T.K.S. Ng, C.S.H. Ho, W.W.S. Tam, et al., Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis, Int. J. Mol. Sci. 20 (2019) 257. https://doi.org/10.3390/ijms20020257.
Crossref Google Scholar
[70]

S.V. Maurer, C.L. Williams, The cholinergic system modulates memory and hippocampal plasticity via its interactions with non-neuronal cells, Front. Immunol. 8 (2017) 1489. https://doi.org/10.3389/fimmu.2017.01489.
Crossref Google Scholar
[71]

T.N. Luong, H.J. Carlisle, A. Southwell, et al., Assessment of motor balance and coordination in mice using the balance beam, J. Vis. Exp. 49 (2011) 2376. https://doi.org/10.3791/2376.
Crossref Google Scholar
[72]

M.L. Seibenhener, M.C. Wooten, Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice, J. Vis. Exp. 96 (2015) e52434. https://doi.org/10.3791/52434.
Crossref Google Scholar
[73]

T.N. Taylor, J.G. Greene, G.W. Miller, Behavioral phenotyping of mouse models of Parkinson's disease, Behav. Brain Res. 211 (2010) 1-10. https://doi.org/10.1016/j.bbr.2010.03.004.
Crossref Google Scholar
[74]

M.Y. Yew, R.Y. Koh, S.M. Chye, et al., Neurotrophic properties and the de novo peptide sequencing of edible bird's nest extracts, Food Biosci. 32 (2019) 100466. https://doi.org/10.1016/j.fbio.2019.100466.
Crossref Google Scholar
[75]

S.E. Marsh, M. Blurton-Jones, Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support, Neurochem. Int. 106 (2017) 94-100. https://doi.org/10.1016/j.neuint.2017.02.006.
Crossref Google Scholar
[76]

D.A. Steindler, B.A. Reynolds, Perspective: neuroregenerative nutrition, Adv. Nutr. 8 (2017) 546-557. https://doi.org/10.3945/an.117.015388.
Crossref Google Scholar
[77]
OECD, OECD guideline for testing of chemicals: acute oral toxicity - acute toxic class method, (2001).
[78]

P.E. Kew, S.F. Wong, P.K. Lim, et al., Structural analysis of raw and commercial farm edible bird nests, Trop. Biomed. 31 (2014) 63-76.
Google Scholar
[79]

D.L. Goh, K.Y. Chua, F.T. Chew, et al., Immunochemical characterization of edible bird's nest allergens, J. Allergy Clin. Immunol. 107 (2001) 1082-1087. https://doi.org/10.1067/mai.2001.114342.
Crossref Google Scholar
[80]
Standard and Industrial Research Institute of Malaysia (SIRIM), Edible bird nest (EBN) specification (MS 2334: 2011), Selangor, Malaysia, 2011.
[81]

A.A.M. Ali, H.S.M. Noor, P.K. Chong, et al., Comparison of amino acids profile and antioxidant activities between edible bird nest and chicken egg, Malays. Appl. Biol. 48 (2019) 63-69.
Google Scholar
[82]

S.R. Ng, H.S.M. Noor, R. Ramachandran, et al., Recovery of glycopeptides by enzymatic hydrolysis of edible bird's nest: the physicochemical characteristics and protein profile, J. Food Meas. Charact. 14 (2020) 2635-2645. https://doi.org/10.1007/s11694-020-00510-4.
Crossref Google Scholar
[83]

M.Z.N. Huda, A.B.Z. Zuki, K. Azhar, et al., Proximate, elemental and fatty acid analysis of pre-processed edible birds' nest (Aerodramus fuciphagus): a comparison between regions and type of nest, J. Food Technol. 6 (2008) 39-44.
Google Scholar
[84]

N.A. Daud, S.M. Yusop, A.S. Babji, et al., Edible bird ' s nest: physicochemical properties, production, and application of bioactive extracts and glycopeptides, Food Rev. Int. 37 (2019) 1-20. https://doi.org/10.1080/87559129.2019.1696359.
Crossref Google Scholar
[85]

W. Saengkrajang, N. Matan, N. Matan, Nutritional composition of the farmed edible bird's nest (Collocalia fuciphaga) in Thailand, J. Food Compost. Anal. 31 (2013) 41-45.
Crossref Google Scholar
[86]

Z. Hamzah, N.H. Ibrahim, S.J. Lim, et al., Nutritional properties of edible bird nest, J. Asian Sci. Res. 3 (2013) 600-607.
Google Scholar
[87]

M. Norhayati, O. Azman, W.N. Wan Mohamud, Preliminary study of the nutritional content of Malaysian edible bird's nest, Malays. J. Nutr. 16 (2010) 389-396.
Google Scholar
[88]

M.C. Quek, N.L. Chin, Y.A. Yusof, et al., Characterization of edible bird's nest of different production, species and geographical origins using nutritional composition, physicochemical properties and antioxidant activities, Food Res. Int. 109 (2018) 35-43. https://doi.org/10.1016/j.foodres.2018.03.078.
Crossref Google Scholar
[89]

M.F. Marcone, Characterization of the edible bird's nest the "Caviar of the East", Food Res. Int. 38 (2005) 1125-1134. https://doi.org/10.1016/j.foodres.2005.02.008.
Crossref Google Scholar
[90]

S.N. Tan, D. Sani, C.W. Lim, et al., Proximate analysis and safety profile of farmed edible bird's nest in Malaysia and its effect on cancer cells, Evid. Based Complement. Alternat. Med. 2020 (2020) 8068797. https://doi.org/10.1155/2020/8068797.
Crossref Google Scholar
[91]

E.K. Seow, B. Ibrahim, S.A. Muhammad, et al., Differentiation between house and cave edible bird's nests by chemometric analysis of amino acid composition data, LWT-Food Sci. Technol. 65 (2016) 428-435. https://doi.org/10.1016/j.lwt.2015.08.047.
Crossref Google Scholar
[92]

N.M. Halimi, Z.M. Kasim, A.S. Babji, Nutritional composition and solubility of edible bird nest (Aerodramus fuchiphagus), AIP Conf. Proc. 1614 (2014) 476-481. https://doi.org/10.1063/1.4895243.
Crossref Google Scholar
[93]

A.M. Amin, X.X. Oon, N. Sarbon, Optimization of enzymatic hydrolysis conditions on the degree of hydrolysis of edible bird's nest using Alcalase® and nutritional composition of the hydrolysate, Food Res. 3 (2019) 570-580.
Crossref Google Scholar
[94]

D.A. Zulkifli, R. Mansor, M.M.M. Ajat, et al., Differentiation of Malaysian farmed and commercialised edible bird's nests through nutritional composition analysis, Pertanika J. Trop. Agric. Sci. 42 (2019) 871-881. http://psasir.upm.edu.my/id/eprint/71159.
Google Scholar
[95]

M. Ghassem, K. Arihara, S. Mohammadi, et al., Identification of two novel antioxidant peptides from edible bird's nest (Aerodramus fuciphagus) protein hydrolysate, Food Funct. 8 (2017) 2046–2052. https://doi.org/10.1039/c6fo01615d.
Crossref Google Scholar
[96]

N.A. Daud, S.R. Sarbini, A.S. Babji, et al., Characterization of edible swiftlet's nest as a prebiotic ingredient using a simulated colon model, Ann. Microbiol. 69 (2019) 1235-1246. https://doi.org/10.1007/s13213-019-01507-1.
Crossref Google Scholar
[97]

H.L. Ting, H.L. Chia, A.A. Nurul, et al., Characterization of polar and non-polar compounds of house edible bird's nest (EBN) from Johor, Malaysia, Chem. Biodivers. 17 (2020) 419. https://doi.org/10.1002/cbdv.201900419.
Crossref Google Scholar
[98]

M. Saeidi, R. Shakeri, A. Marjani, et al., Alzheimer's disease and paraoxonase 1 (PON1) gene polymorphisms, Open Biochem. J. 11 (2017) 47-55.
Crossref Google Scholar
[99]

F. Ma, D. Liu, Extraction and determination of hormones in the edible bird's nest, Asian J. Chem. 24 (2012) 117-120.
Google Scholar
[100]
L. Yang, C. Cai, J. Lin, et al., Simultaneous detection of estrogenic and progestogenic hormones in edible bird's nest by ultra-performance liquid chromatography tandem mass spectrometry, PerkinElmer, Inc. (2016) 1-4.
[101]

R.L. Schnaar, R. Gerardy-Schahn, H. Hildebrandt, Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration, Physiol. Rev. 94 (2014) 461-518. https://doi.org/10.1152/physrev.00033.2013.
Crossref Google Scholar
[102]

C.H. Tung, J.Q. Pan, H.M. Chang, et al., Authentic determination of bird's nests by saccharides profile, J. Food Drug Anal. 16 (2008) 86-91. https://doi.org/10.38212/2224-6614.2339.
Crossref Google Scholar
[103]

J.W.A. Ling, L.S. Chang, A.S. Babji, et al., Recovery of value-added glycopeptides from edible bird's nest (EBN) co-products: enzymatic hydrolysis, physicochemical characteristics and bioactivity, J. Sci. Food Agric. 100 (2020) 4714-4722. https://doi.org/10.1002/jsfa.10530.
Crossref Google Scholar
[104]

H.K. Kong, K.H. Wong, S.C.L. Lo, Identification of peptides released from hot water insoluble fraction of edible bird's nest under simulated gastro-intestinal conditions, Food Res. Int. 85 (2016) 19-25. https://doi.org/10.1016/j.foodres.2016.04.002.
Crossref Google Scholar
[105]

O. Gonzalez-Perez, A. Quiñones-Hinojosa, Dose-dependent effect of EGF on migration and differentiation of adult subventricular zone astrocytes, Glia 58 (2010) 975-983. https://doi.org/10.1002/glia.20979.
Crossref Google Scholar
[106]

S.N. Zukefli, L.S. Chua, Z. Rahmat, Protein extraction and identification by gel electrophoresis and mass spectrometry from edible bird's nest samples, Food Anal. Methods 10 (2017) 387-398.
Crossref Google Scholar
[107]

M. Ismail, A. Alsalahi, M.A. Aljaberi, et al., Efficacy of edible bird's nest on cognitive functions in experimental animal models: a systematic review, Nutrients 13 (2021) 1028. https://doi.org/10.3390/nu13031028.
Crossref Google Scholar
[108]

S. Marni, M. Marzura, A. Norzela, Preliminary study on free sialic acid content of edible bird nest from Johor and Kelantan, Malays. J. Vet. Res. 5 (2014) 9-14.
Google Scholar
[109]

Z.C.F. Wong, G.K.L. Chan, K.Q.Y. Wu, et al., Complete digestion of edible bird's nest releases free N-acetylneuraminic acid and small peptides: an efficient method to improve functional properties, Food Funct. 9 (2018) 5139-5149. https://doi.org/10.1039/c8fo00991k.
Crossref Google Scholar
[110]

Y.Q. Yu, L. Xue, H. Wang, et al., Determination of edible bird's nest and its products by gas chromatography, J. Chromatogr. Sci. 38 (2000) 27-32. https://doi.org/10.1093/chromsci/38.1.27.
Crossref Google Scholar
Food Science and Human Wellness
Volume 12 Issue 4,
July 2023
Pages 1008-1019
DOI: 10.1016/j.fshw.2022.10.021
Cite this article:
Chu W, Phan CW, Lim SJ, et al. Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents. Food Science and Human Wellness, 2023, 12(4): 1008-1019. https://doi.org/10.1016/j.fshw.2022.10.021

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Received: 07 February 2022
Revised: 10 March 2022
Accepted: 22 May 2022
Published: 18 November 2022
© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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