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Research Article | Open Access

Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota

Tao Wanga,b, Panpan Wanga, Li Yina, Xiuchao Wanga, Yuanyuan Shana, Yanglei Yia, Yuan Zhoua, Bianfang Liua( ), Xin Wanga( ), Xin Lüa( )
College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, China
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2% dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.

Keywords

Gut microbiotaInflammationColorectal cancerLactiplantibacillus plantarum KX041Intestinal permeability

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Food Science and Human Wellness
Volume 12 Issue 5,
September 2023
Pages 1626-1636
DOI: 10.1016/j.fshw.2023.02.012
Cite this article:
Wang T, Wang P, Yin L, et al. Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota. Food Science and Human Wellness, 2023, 12(5): 1626-1636. https://doi.org/10.1016/j.fshw.2023.02.012

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Received: 10 March 2021
Revised: 07 April 2021
Accepted: 21 April 2021
Published: 21 March 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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