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Research Article | Open Access

Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism

Aamina Alima, Ting Lia( ), Tanzeela Nisarb, Zeshan Alic, Daoyuan Rena, Yueyue Liua, Xingbin Yanga( )
Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China
Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Lahore 54000, Pakistan
Department of Life sciences, Barani Institution, Sahiwal 57000, Pakistan

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

This study aimed to investigate the protective effects of fleshes from two Actinidia chinensis (ACF), pericarps from two A. chinensis (ACP), and fleshes with pericarps from two A. chinensis (ACFP) on high fructose (HF)-instigated dyslipidemia, hepatic steatosis, oxidative stress, insulin resistance, and fatty acid metabolism disorders in rats. In general, the above abnormalities were improved after 10 weeks intervention of ACF, ACP, and ACFP. Especially, ACFP considerably ameliorated HF-induced abnormal changes in body weight gain, serum TC, TG, LDL-C and HDL-C levels, as well as serum and hepatic SFAs, MUFAs and PUFAs contents. ACFP also alleviated HF-induced hyperglycemia and hyperinsulinemia, stabilized HF-caused increase in hepatic MDA and serum ALT, AST levels, and restored HF-declined hepatic T-SOD and GSH-Px activities. Besides, histopathology of the liver further endorsed the protective effects of ACFP on hepatocellular injury. Moreover, ACFP increased HF-dropped acetic, propionic and butyric acid levels. Overall, ACFP employs more efficacious protective effects against HF-induced metabolic disorders and liver damage than ACF and ACP. This study delivers a scientific foundation for developing kiwifruit (counting peel)-based dietary supplements for those with glucolipid-metabolic disorders and liver damage.

Keywords

Oxidative stressInsulin resistanceActinidia chinensis peelLipid homeostasisHepatocellular injuryFatty acid metabolism

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Food Science and Human Wellness
Volume 12 Issue 5,
September 2023
Pages 1872-1884
DOI: 10.1016/j.fshw.2023.02.039
Cite this article:
Alim A, Li T, Nisar T, et al. Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism. Food Science and Human Wellness, 2023, 12(5): 1872-1884. https://doi.org/10.1016/j.fshw.2023.02.039

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Received: 28 March 2022
Revised: 12 May 2022
Accepted: 31 May 2022
Published: 21 March 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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