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Research Article | Open Access

Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial

Chia-Hua Lianga, Yung-Hsiang Linb, Yung-Kai Linc,d( ), Chi-Fu Chiangb( )
Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 71710, China
Research & Design Center, TCI CO., Ltd., Taipei 114722, China
Institute of Food Safety and Risk Management, Department of Food Science, Taiwan Ocean University, Keelung 202301, China
Graduate Institute of Biomedical Engineering, Chung Hsing University, Taichung 202301, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract (HappyAngel®) was used to treat human hair follicle dermal papilla cells (HFDPCs) and the expression of reactive oxygen species (ROS), dihydrotestosterone (DHT), and hair-related genes (SRD5A1, SRD5A2, AR, and KROX20) were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract (HappyAngel®) can stimulate hair growth and inhibit the activation of hair loss genes.

Keywords

ROSBanana flowerDihydrotestosteroneHair lossFollicle dermal papilla cells

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Food Science and Human Wellness
Volume 12 Issue 5,
September 2023
Pages 1917-1923
DOI: 10.1016/j.fshw.2023.02.043
Cite this article:
Liang C-H, Lin Y-H, Lin Y-K, et al. Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial. Food Science and Human Wellness, 2023, 12(5): 1917-1923. https://doi.org/10.1016/j.fshw.2023.02.043

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Received: 14 June 2022
Revised: 12 July 2022
Accepted: 02 August 2022
Published: 21 March 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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