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Research Article | Open Access

Flammulina velutipes polysaccharide-iron(Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters

Chenying Shia,1, Chen Chenga,1, Xiaotong Lina, Yanfang Qiana, Yufeng Dub( ), Guitang Chena( )
Department of Food Nutrition and Safety/National R&D Center for Chinese Herbal, Medicine Processing, China Pharmaceutical University, Nanjing 211198, China
College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

1 These authors contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Iron deficiency anemia (IDA) is a common nutritional problem, but traditional iron supplements cause many adverse reactions. Thus, the development of a novel iron supplement might be significant for the treatment of IDA. This study aimed to study the transport mechanism of Flammulina velutipes polysaccharide-iron complex (FVP1-Fe(Ⅲ)) in Caco-2 cells and the therapeutic effect on IDA rats, as well as the influence on gut microbiota in vivo. These results showed that in vitro, the uptake of FVP1-Fe(Ⅲ) was mediated by sodium-dependent glucose transporter-1 (SGLT1) and facilitated glucose transporter-2 (GLUT2) and GLUT2 played a dominant function. The multidrug resistance-associated protein-2 (MRP-2) was involved in the efflux of FVP1-Fe(Ⅲ) across the Caco-2 cells. In vivo, FVP1-Fe(Ⅲ) had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(Ⅲ) could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. Besides, as a dietary factor, vitamin C (vit C) could enhance the therapeutic effect of FVP1-Fe(Ⅲ). These present findings showed that FVP1-Fe(Ⅲ) could be exploited as a novel iron supplement to treat IDA.

Keywords

Gut microbiotaIron deficiency anemiaFlammulina velutipes polysaccharideIron supplementCaco-2 cell model

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Food Science and Human Wellness
Volume 12 Issue 5,
September 2023
Pages 1828-1840
DOI: 10.1016/j.fshw.2023.02.047
Cite this article:
Shi C, Cheng C, Lin X, et al. Flammulina velutipes polysaccharide-iron(Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters. Food Science and Human Wellness, 2023, 12(5): 1828-1840. https://doi.org/10.1016/j.fshw.2023.02.047

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Received: 04 January 2022
Revised: 09 February 2022
Accepted: 28 March 2022
Published: 21 March 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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