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Research Article | Open Access

Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression

Zhenhua Liua,b,c, Mengke Wanga, Lijun Menga, Yixiao Chena, Qiuyi Wanga, Yan Zhangd( ), Xuefeng Xia,e( ), Wenyi Kanga,b,c( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Functional Food Engineering Technology Research Center, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng 475004, China
Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, Key Laboratory of Special Food Supervision Technology for State Market Regulation, Hebei Engineering Research Center for Special Food Safety and Health, Shijiazhuang 050017, China
College of Physical Education, Henan University, Kaifeng 475004, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Patrinia scabiosaefolia, is used as wild vegetable in China for more than 2 000 years, with a variety of pharmacological activities, including anti-inflammatory, anti-tumor and hypoglycemic. Based on our ongoing research on chemical constituents and hypoglycemic activity of P. scabiosaefolia, 4 lignan compounds, (+)-isolariciresinol (1), 7R,7′R,8S,8′S-(+)-neo-olivil-4-O-β-D-glucopyranoside (2), 4-O-methylcedrusin (3) and patrinian A (4), were isolated and identified. The hypoglycemic activity showed that compounds 2 and 3 could extremely significantly improve insulin resistance at 100 (P < 0.001), 50 (P < 0.001) and 25 µmol/L (P < 0.01) in IR 3T3-L1 cells. While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100 µmol/L (P < 0.01). Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS, PI-3K, p-AKT and glucose transporter 4 (GLUT4), and promoted the transcription of GLUT4 mRNA. Therefore, the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway.

Keywords

Insulin resistancePatrinia scabiosaefoliaPatrinian A7R,7′R,8S,8′S-(+)-neo-olivil-4-O-β-D-glucopyranoside

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Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 2014-2021
DOI: 10.1016/j.fshw.2023.03.015
Cite this article:
Liu Z, Wang M, Meng L, et al. Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression. Food Science and Human Wellness, 2023, 12(6): 2014-2021. https://doi.org/10.1016/j.fshw.2023.03.015

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Received: 03 March 2022
Revised: 31 March 2022
Accepted: 17 May 2022
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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