AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Food Science and Human Wellness Article
PDF (4.7 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression

Zhenhua Liua,b,c, Mengke Wanga, Lijun Menga, Yixiao Chena, Qiuyi Wanga, Yan Zhangd( ), Xuefeng Xia,e( ), Wenyi Kanga,b,c( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Functional Food Engineering Technology Research Center, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng 475004, China
Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, Key Laboratory of Special Food Supervision Technology for State Market Regulation, Hebei Engineering Research Center for Special Food Safety and Health, Shijiazhuang 050017, China
College of Physical Education, Henan University, Kaifeng 475004, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

Patrinia scabiosaefolia, is used as wild vegetable in China for more than 2 000 years, with a variety of pharmacological activities, including anti-inflammatory, anti-tumor and hypoglycemic. Based on our ongoing research on chemical constituents and hypoglycemic activity of P. scabiosaefolia, 4 lignan compounds, (+)-isolariciresinol (1), 7R,7′R,8S,8′S-(+)-neo-olivil-4-O-β-D-glucopyranoside (2), 4-O-methylcedrusin (3) and patrinian A (4), were isolated and identified. The hypoglycemic activity showed that compounds 2 and 3 could extremely significantly improve insulin resistance at 100 (P < 0.001), 50 (P < 0.001) and 25 µmol/L (P < 0.01) in IR 3T3-L1 cells. While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100 µmol/L (P < 0.01). Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS, PI-3K, p-AKT and glucose transporter 4 (GLUT4), and promoted the transcription of GLUT4 mRNA. Therefore, the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway.

Keywords

Patrinia scabiosaefoliaInsulin resistancePatrinian A7R,7′R,8S,8′S-(+)-neo-olivil-4-O-β-D-glucopyranoside

References

[1]

K. Marianna, Milestones in the history of diabetes mellitus: the main contributors, Word J. Diabetes. 7(1) (2016) 1-7. https://doi.org/10.4239/wjd.v7.i1.1.
Crossref Google Scholar
[2]

N.H. Cho, J.E. Shaw, S. Karuranga, et al., IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045, Diabetes Res. Clin. Pract. 138 (2018) 271-281. https://doi.org/10.1016/j.diabres.2018.02.023.
Crossref Google Scholar
[3]

F. Saadeldeen, Y. Niu, H. Wang, et al., Natural products: regulating glucose metabolism and improving insulin resistance, Food Sci. Hum. Well. 9(3) (2020) 1-15. https://doi.org/10.1016/j.fshw.2020.04.005.
Crossref Google Scholar
[4]

D. Li, Q. Liu, W. Sun, et al., 1,3,6,7-Tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulted in by the paracrine interaction of adipocytes and macrophages, Brit. J. Pharmacol. 175 (2018) 1590-1606. https://doi.org/10.1111/bph.14162.
Crossref Google Scholar
[5]

C.C. Chen, C.K. Lii, Y.H. Lin, et al., Andrographis paniculata improves insulin resistance in high-fat diet-induced obese mice and TNFα-treated 3T3-L1 adipocytes, Am. J. Chin. Med. 48(5) (2020) 1073-1090. https://doi.org/10.1142/S0192415X20500524.
Crossref Google Scholar
[6]

A. Molinaro, B. Becattini, A. Mazzoli, et al., Insulin-driven PI3K-AKT signaling in the hepatocyte is mediated by redundant PI3Kα and PI3Kβ activities and is promoted by RAS, Cell Metab. 30 (2019) 1-10. https://doi.org/10.1016/j.cmet.2019.03.010.
Crossref Google Scholar
[7]

X. Huang, G. Liu, J. Guo, et al., The PI3K/AKT pathway in obesity and type 2 diabetes, Int. J. Biol. Sci. 14(11) (2018) 1483-1496. https://doi.org/10.7150/ijbs.27173.
Crossref Google Scholar
[8]

T. Joshi, A.K. Singh, P. Haratipour, et al., Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications, J. Cell. Physiol. 234(10) (2019) 17212-17231. https://doi.org/10.1002/jcp.28528.
Crossref Google Scholar
[9]

L. Meng, S. Chen, L. Zhou, et al., Chemical constituents and pharmacological effects of genus patrinia: a review, Curr. Pharmacol. Rep. 6(6) (2020) 1-35. https://doi.org/10.1007/s40495-020-00240-7.
Crossref Google Scholar
[10]

Z. Liu, Y. Niu, L. Zhou, et al., Nine unique iridoids and iridoid glycosides from Patrinia scabiosaefolia, Front. Chem. 9 (2021) 657028-657041. https://doi.org/10.3389/fchem.2021.657028.
Crossref Google Scholar
[11]

Z. Liu, L. Xu, X. Xu, et al., Effects and mechanisms of iridoid glycosides from Patrinia scabiosaefolia on improving insulin resistance in 3T3-L1 adipocytes, Food Chem. Toxicol. 134 (2019) 110806-110811. https://doi.org/10.1016/j.fct.2019.110806.
Crossref Google Scholar
[12]

A.J. Deng, H.J. Zhang, Z.H. Zhang, et al., Constituents with anti-oxidative activity from seeds of Jufeng grape, China J. Chin. Mater Med. 40(21) (2015) 4208-4211. https://doi.org/10.4268/cjcmm20152117.
Crossref Google Scholar
[13]

M. Kikuchi, M. Kikuchi, Studies on the constituents of Swertia japonica Makino Ⅱ. On the structures of new glycosides, Chem Pharm Bull. 53(30) (2005) 48-51. https://doi.org/10.1002/chin.200530175.
Crossref Google Scholar
[14]

L. Pieters, T.D. Bruyne, M. Claeys, et al., Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation, J. Nat. Prod. 56(6) (1993) 899-906. https://doi.org/10.1021/np50096a013.
Crossref Google Scholar
[15]

F. Zhou, K. Furuhashi, M.J. Son, et al., Antidiabetic effect of enterolactone in cultured muscle cells and in type 2 diabetic model db/db mice, Cytotechnology. 63(9) (2017) 493-502. https://doi.org/10.1007/s10616-016-9965-2.
Crossref Google Scholar
[16]

L. Cui, J. Wang, M. Wang, et al., Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. Flowers, Food Sci. Hum. Wellness. 9(2) (2020) 124-129. https://doi.org/10.1016/j.fshw.2020.02.002.
Crossref Google Scholar
[17]

X. Xu, P. Wang, B. Wang, et al., Glucose absorption regulation and mechanism of the compounds in Lilium lancifolium Thunb. on Caco-2 cells, Food Chem. Toxicol. 149 (2021) 112010-112017. https://doi.org/10.1016/j.fct.2021.112010.
Crossref Google Scholar
[18]

L. Chen, X. Fan, X. Lin, et al., Phenolic extract from Sonchus oleraceus L. protects diabetes-related liver injury in rats through TLR4/NF-κB Signaling pathway, eFood. 1(1) (2019)77-84. https://doi.org/10.2991/efood.k.191018.002.
Crossref Google Scholar
[19]

L. Sun, L. Bao, D. Phurbu, et al., Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice, Food Sci. Hum. Well. 10(4) (2021) 442-451. https://doi.org/10.1016/j.fshw.2021.04.006.
Crossref Google Scholar
[20]

Z. Wei, X. Wen, Z. Yi, et al., Metabolomic study on the preventive effect of Patrinia Scabiosaefolia fisch on multipathogen induced pelvic inflammatory disease in rats, Evid. Based Complement. Altern. Med. 2015 (2015) 170792-170801. https://doi.org/10.1155/2015/170792.
Crossref Google Scholar
[21]

M. Zhang, G. Sun, A. Shen, et al., Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest, Oncol. Rep. 33(2) (2015) 856-860. https://doi.org/10.3892/or.2014.3663.
Crossref Google Scholar
[22]

K. Prasad, Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat, J. Lab. Clin. Med. 138(1) (2001) 32-39. https://doi.org/10.1067/mlc.2001.115717.
Crossref Google Scholar
[23]

S. Jian, Y. Tang, Y. Xiao, et al., Flaxseed lignans alleviate high fat diet-induced hepatic steatosis and insulin resistance in mice: potential involvement of AMP-activated protein kinase, J. Funct. Foods. 24 (2016) 482-491. https://doi.org/10.1016/j.jff.2016.04.032.
Crossref Google Scholar
[24]

S. Ghaderi, M. Rashno, A. Nesari, et al., Sesamin alleviates diabetes-associated behavioral deficits in rats: the role of inflammatory and neurotrophic factors, Int. Immunopharmacol. 92 (2021) 107356-107365. https://doi.org/10.1016/j.intimp.2020.107356.
Crossref Google Scholar
[25]

Z. Lei, I.B. Tan, K. Das, et al., Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil, Gastroenterology. 45(3) (2013) 554-565. https://doi.org/10.1053/j.gastro.2013.05.010.
Crossref Google Scholar
[26]

M. Feng, F. Liu, J. Xing, et al., Anemarrhena aponins attenuate insulin resistance in rats with high-fat diet-induced obesity via the IRS-1/PI3K/AKT pathway, J. Ethnopharmacol. 277(4) (2021) 114251-114260. https://doi.org/10.1016/j.jep.2021.114251.
Crossref Google Scholar
[27]

R. Govers, Molecular mechanisms of GLUT4 regulation in adipocytes, Diabetes Metab. 40(6) (2014) 400-410. https://doi.org/10.1016/j.diabet.2014.01.005.
Crossref Google Scholar
[28]

P.H. Nguyen, T.V.T. Le, H.W. Kang, et al., AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect, Bioorg. Chem. 20(14) (2010) 4128-4131. https://doi.org/10.1016/j.bmcl.2010.05.067.
Crossref Google Scholar
[29]

M. Bai, G.D. Yao, S.F. Liu, et al., Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer's disease, J. Funct. Foods. 28 (2017) 106-113. https://doi.org/10.1016/j.jff.2016.10.024.
Crossref Google Scholar
[30]

Y. Zhu, R.Z. Huang, C.G. Wang, et al., New inhibitors of matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellendorffii, Fitoterapia. 130 (2018) 281-289. https://doi.org/10.1016/j.fitote.2018.09.008.
Crossref Google Scholar
[31]

C. Zhao, J. Chen, J. Shao, et al., Neolignan constituents with potential beneficial effects in prevention of type 2 diabetes from Viburnum fordiae Hance fruits, J. Agric. Food Chem. 66(40) (2018) 10421-10430. https://doi.org/10.1021/acs.jafc.8b03772.
Crossref Google Scholar
Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 2014-2021
DOI: 10.1016/j.fshw.2023.03.015
Cite this article:
Liu Z, Wang M, Meng L, et al. Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression. Food Science and Human Wellness, 2023, 12(6): 2014-2021. https://doi.org/10.1016/j.fshw.2023.03.015

687

Views

28

Downloads

3

Crossref

3

Web of Science

3

Scopus

0

CSCD

Altmetrics
Received: 03 March 2022
Revised: 31 March 2022
Accepted: 17 May 2022
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return