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Research Article | Open Access

Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages

Shanshan Tiea,b, Lijuan Zhanga, Bin Lic, Shanghua Xinga, Haitao Wanga, Yannan Chena, Weina Cuia, Shaobin Gub, Mingqian Tana( )
Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China
College of Food Science, Shenyang Agricultural University, National R&D Professional Center for Berry Processing, Shenyang 110866, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Inflammation plays an important role in the occurrence and development of many inflammatory diseases. The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins (PC) nanoparticles on lipopolysaccharide (LPS)-stimulated inflammatory macrophages by metabolomics method. The double-targeting PC nanoparticles could specifically target both the CD44 receptor and mitochondria, while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of macrophages. The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS. Amino acid metabolism, energy metabolism and purine metabolism were disordered in LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts. The changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation, and promote their application in nutrition intervention.

Keywords

InflammationMacrophagesMetabolomicsLipopolysaccharideProcyanidins nanoparticles

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Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 2252-2262
DOI: 10.1016/j.fshw.2023.03.045
Cite this article:
Tie S, Zhang L, Li B, et al. Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages. Food Science and Human Wellness, 2023, 12(6): 2252-2262. https://doi.org/10.1016/j.fshw.2023.03.045

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Received: 20 June 2022
Revised: 09 August 2022
Accepted: 17 August 2022
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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