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Commentary | Open Access

RhoA, a novel tumor suppressor or oncogene as a therapeutic target?

Melissa Gilbert-RossAdam I. MarcusWei Zhou,( )
The Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA

Peer review under responsibility of Chongqing Medical University.

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Avraham H, Weinberg RA. Characterization and expression of the human rhoH12 gene product. Mol Cell Biol. May 1989;9:2058–2066.

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Palomero T, Couronne L, Khiabanian H, et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet. Feb 2014;46:166–170.

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Yoo HY, Sung MK, Lee SH, et al. A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet. Apr 2014;46:371–375.

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Manso R, Sanchez-Beato M, Monsalvo S, et al. The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature. Blood. May 1 2014;123:2893–2894.
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Kakiuchi M, Nishizawa T, Ueda H, et al. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet. Jun 2014;46:583–587.

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The Cancer Genome Atlas Research N, Analysis Working Group: Dana-Farber Cancer I, Institute for Systems B, et al. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. Jul 23 2014.
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Wang K, Yuen ST, Xu J, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. Jun 2014;46:573–582.

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Zhou X, Zheng Y. Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting. J Biol Chem. Dec 20 2013;288:36179–36188.
Genes & Diseases
Pages 2-3
Cite this article:
Gilbert-Ross M, Marcus AI, Zhou W. RhoA, a novel tumor suppressor or oncogene as a therapeutic target?. Genes & Diseases, 2015, 2(1): 2-3. https://doi.org/10.1016/j.gendis.2014.10.001

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Received: 04 October 2014
Published: 01 November 2014
© 2014, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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