AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (300.5 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article | Open Access

Deciphering the role of microRNA 21 in cancer stem cells (CSCs)

Durairaj Sekara,b,( ), Ramalingam Krishnana, Mani Panagalc, Pethanen Sivakumard, Vincent Gopinathd, Venugopal Basamb
Narayana Medical College and Hospital, Chinthareddypalem, Nellore 524002, India
Stem Cell Division, Cryovault Biotech India Pvt Ltd, Bangalore 560018, India
Department of Biotechnology, Annai College of Arts and Science, Kumbakonam, Tamil Nadu, India
Department of Zoology, Arumugam Pillai Seethai Ammal College, Tiruppattur, Tamil Nadu, India

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21–25 nucleotides (nt) in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3′-untranslated (UTR) region and play a very important role in cancer biology. Recent evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation, apoptosis, and invasion. Even though an increased expression level of miR-21 has been observed in cancer stem cells, studies related to the role of miR-21 in cancer stem cells are limited. The main aim of this mini review is to explain the potency of miR-21 in various cancer stem cells (CSCs) and as a new target for therapeutic interventions of cancer progression.

Keywords

miRNAsCancer stem cellsmiR-21CSCsRNAsUTR

References

1

Takahashi RU, Miyazaki H, Ochiya T. The role of microRNAs in the regulation of cancer stem cells. Front Genet. 2014;4:295.
Crossref Google Scholar
2

Colmont CS, Harding KG, Piguet V, Patel GK. Human skin cancer stem cells: a tale of mice and men. Exp Dermatol. 2012;21:576-580.
Crossref Google Scholar
3

Karsten U, Goletz S. What makes cancer stem cell markers different? SpringerPlus. 2013;2:301. http://dx.doi.org/10.1186/2193-1801-2-301.
Crossref Google Scholar
4

Sekar D, Hairul Islam VI, Thirugnanasambantham K, Saravanan S. Relevance of miR-21 in HIV and non-HIV-related lymphomas. Tumour Biol. 2014;35:8387-8393.
Crossref Google Scholar
5

Sekar D, Saravanan S, Karikalan K, et al. Role of microRNA 21 in mesenchymal stem cell (MSC) differentiation: a powerful biomarker in MSCs derived cells. Curr Pharm Biotechnol. 2015;16:43-48.
Crossref Google Scholar
6

Venturutti L, Romero LV, Urtreger AJ, et al. Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis. Oncogene. 2015;35:2208-2222.
Crossref Google Scholar
7

Cappellesso R, Tinazzi A, Giurici T, et al. Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions. Cancer Cytopathol. 2014;122:685-693.
Crossref Google Scholar
8

Deftereos G, Corrie SR, Feng Q, et al. Expression of mir-21 and mir-143 in cervical specimens ranging from histologically normal through to invasive cervical cancer. PLoS One. 2011;6:e28423.
Crossref Google Scholar
9

Tao YJ, Li YJ, Zheng W, et al. Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. Cancer Cell Int. 2015;15:77.
Crossref Google Scholar
10

Zhang J, Zhang C, Hu L, et al. Abnormal expression of miR-21 and miR-95 in cancer stem-like cells is associated with radioresistance of lung cancer. Cancer Invest. 2015;33:165-171.
Crossref Google Scholar
11

Mao B, Xiao H, Zhang Z, et al. MicroRNA21 regulates the expression of BTG2 in HepG2 liver cancer cells. Mol Med Rep. 2015;12:4917-4924.
Crossref Google Scholar
12

Li L, Zhou L, Li Y, et al. MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog. J BUON. 2014;19:228-236.
Google Scholar
13

Yamanaka S, Olaru AV, An F, et al. MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer. Dig Liver Dis. 2012;44:589-596.
Crossref Google Scholar
14

Si ML, Zhu S, Wu H, et al. miR-21-mediated tumor growth. Oncogene. 2007;26:2799-2803.
Crossref Google Scholar
15

Yu Y, Nangia-Makker P, Farhana L, et al. miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. Mol Cancer. 2015;14:98.
Crossref Google Scholar
16

Shang C, Guo Y, Hong Y, Liu YH, Xue YX. MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG. Mol Biol Rep. 2015;42:721-727.
Crossref Google Scholar
17

Kang HY. MicroRNA-21 regulates stemness in cancer cells. Stem Cell Res Ther. 2013;4:110.
Crossref Google Scholar
18

Mamoori A, Gopalan V, Smith RA, Lam AK. Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells. Biol Cell. 2016;108:51-64.
Crossref Google Scholar
19

Haghpanah V, Fallah P, Tavakoli R, et al. Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Tumour Biol. 2015;37:1299-1308.
Crossref Google Scholar
20

Chung WM, Chang WC, Chen L, et al. MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. Stem Cell Res Ther. 2013;4:88.
Crossref Google Scholar
21

Zhou L, Yang ZX, Song WJ, et al. MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma. Int J Oncol. 2013;43:661-669.
Crossref Google Scholar
22

Sanchez-Diaz PC, Hsiao TH, Chang JC, et al. De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development. PLoS One. 2013;8:e61622.
Crossref Google Scholar
23

Zhang S, Wan Y, Pan T, et al. MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide. J Mol Neurosci. 2012;47:346-356.
Crossref Google Scholar
24

Han M, Wang Y, Liu M, et al. MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1α expression in third-sphere forming breast cancer stem cell-like cells. Cancer Sci. 2012;103:1058-1064.
Crossref Google Scholar
25

Golestaneh AF, Atashi A, Langroudi L, Shafiee A, Ghaemi N, Soleimani M. miRNAs expressed differently in cancer stem cells and cancer cells of human gastric cancer cell line MKN-45. Cell Biochem Funct. 2012;30:411-418.
Crossref Google Scholar
26

Han M, Liu M, Wang Y, et al. Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells. Mol Cell Biochem. 2012;363:427-436.
Crossref Google Scholar
27

Misawa A, Katayama R, Koike S, Tomida A, Watanabe T, Fujita N. AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells. Oncol Res. 2010;19:23-33.
Crossref Google Scholar
28

Sekar D, Venugopal B, Sekar P, Ramalingam K. Role of microRNA 21 in diabetes and associated/related diseases. Gene. 2016;582:14-18.
Crossref Google Scholar
29

Trang P, Medina PP, Wiggins JF, et al. Regression of murine lung tumours by the let-7 microRNA. Oncogene. 2009;29:1580-1587.
Crossref Google Scholar
30

Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005;65:6029-6033.
Crossref Google Scholar
Genes & Diseases
Volume 3 Issue 4,
December 2016
Pages 277-281
DOI: 10.1016/j.gendis.2016.05.002
Cite this article:
Sekar D, Krishnan R, Panagal M, et al. Deciphering the role of microRNA 21 in cancer stem cells (CSCs). Genes & Diseases, 2016, 3(4): 277-281. https://doi.org/10.1016/j.gendis.2016.05.002

279

Views

2

Downloads

25

Crossref

N/A

Web of Science

24

Scopus

0

CSCD

Altmetrics
Received: 23 March 2016
Accepted: 24 May 2016
Published: 24 June 2016
© 2016, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return