AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (1.2 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article | Open Access

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

Dan Wanga,b,1, Fengjiao Chenb,1, Tao Zengc,1, Qingxia Tanga, Bing Chena, Ling Chenb, Yan Dongd, Xiaosong Lid,( )
Department of Clinical Laboratory, People's Hospital of Rongchang District, Chongqing, Rongchang 402460, PR China
Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, PR China
Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Province, Chengdu, 611731, PR China
Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China

1 Dan Wang, Fengjiao Chen and Tao Zeng contributed equally to this study.]]>

Show Author Information

Abstract

Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC.

Keywords

miRNAsHCClncRNAsceRNAsncRNAssnoRNAs

References

1

Dominissini D, Moshitch-Moshkovitz S, Schwartz S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201-206.
Crossref Google Scholar
2

Pan T. N6-methyl-adenosine modification in messenger and long non-coding RNA. Trends Biochem Sci. 2013;38(4):204-209.
Crossref Google Scholar
3

Liu N, Parisien M, Dai Q, et al. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA. 2013;19(12):1848-1856.
Crossref Google Scholar
4

Carlile TM, Rojas-Duran MF, Zinshteyn B, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014;515(7525):143-146.
Crossref Google Scholar
5

Weick EM, Miska EA. piRNAs: from biogenesis to function. Development. 2014;141(18):3458-3471.
Crossref Google Scholar
6

Guttman M, Amit I, Garber M, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 2009;458(7235):223-227.
Crossref Google Scholar
7

Jankowsky E, Harris ME. Specificity and non-specificity in RNA-protein interactions. Nat Rev Mol Cell Biol. 2015;16(9):533-544.
Crossref Google Scholar
8

Teng KY, Ghoshal K. Role of noncoding RNAs as biomarker and therapeutic targets for liver fibrosis. Gene Expr. 2015;16(4):155-162.
Crossref Google Scholar
9

Meller VH, Joshi SS, Deshpande N. Modulation of chromatin by noncoding RNA. Annu Rev Genet. 2015;49:673-695.
Crossref Google Scholar
10

Gromesová B, Kubaczková V, Bollová B, et al. Potential of long Non- coding RNA molecules in diagnosis of tumors. Klin Onkol. 2016;29(1):20-28.
Crossref Google Scholar
11

Elling R, Chan J, Fitzgerald KA. Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression. Eur J Immunol. 2016;46(3):504-512.
Crossref Google Scholar
12

Geng Hua, Tan Xiao-Di. Functional diversity of long non-coding RNAs in immune regulation. Genes Dis. 2016;3(1):72-81.
Crossref Google Scholar
13

Li Y, Wang X. Role of long noncoding RNAs in malignant disease (Review). Mol Med Rep. 2016;13(2):1463-1469.
Crossref Google Scholar
14

Liu Yamin, Han Ting-Li, Luo Xiaofang, et al. The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia. Genes Dis. 2018;5(3):235-244.
Crossref Google Scholar
15

Briggs JA, Wolvetang EJ, Mattick JS, et al. Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron. 2015;88(5):861-877.
Crossref Google Scholar
16

Yu X, Li Z. Long non-coding RNA growth arrest-specific transcript 5 in tumor biology. Oncol Lett. 2015;10(4):1953-1958.
Crossref Google Scholar
17

Sugihara H, Ishimoto T, Miyake K, et al. Noncoding RNA expression aberration is associated with cancer progression and is a potential biomarker in esophageal squamous cell carcinoma. Int J Mol Sci. 2015;16(11):27824-27834.
Crossref Google Scholar
18

Tao H, Yang JJ, Zhou X, et al. Emerging role of long noncoding RNAs in lung cancer: current status and future prospects. Respir Med. 2016;110:12-19.
Crossref Google Scholar
19

Ouyang J, Hu J, Chen JL. lncRNAs regulate the innate immune response to viral infection. Wiley Interdiscip Rev RNA. 2016;7(1):129-143.
Crossref Google Scholar
20

Lin Z, Hu Y, Lai S, et al. Long Noncoding RNA: its partners and their roles in cancer. Neoplasma. 2015;62(6):846-854.
Crossref Google Scholar
21

Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov. 2011;1(5):391-407.
Crossref Google Scholar
22

Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009;136(4):629-641.
Crossref Google Scholar
23

Kumar Mohan M, Goyal Ravi. LncRNAs as a therapeutic target for angiogenesis. Curr Top Med Chem. 2017;17(15):1750-1757.
Crossref Google Scholar
24

Ma L, Bajic VB, Zhang Z. On the classification of long non-coding RNAs. RNA Biol. 2013;10(6):925-933.
Crossref Google Scholar
25

Li P, Zhang G, Li J, et al. Long noncoding RNA RGMB-AS1 indicates a poor prognosis and modulates cell proliferation, migration and invasion in lung adenocarcinoma. PLoS One. 2016;11(3),e0150790.
Crossref Google Scholar
26

Wilk R, Hu J, Blotsky D, et al. Diverse and pervasive subcellular distributions for both coding and long noncoding RNAs. Genes Dev. 2016;30(5):594-609.
Crossref Google Scholar
27

Chen K, Zhao BS, He C. Nucleic acid modifications in regulation of gene expression. Cell Chem Biol. 2016;23(1):74-85.
Crossref Google Scholar
28

Wang J, Sun J, Wang J, et al. Long noncoding RNAs in gastric cancer: functions and clinical applications. OncoTargets Ther. 2016;9:681-697.
Crossref Google Scholar
29

Wang J, Xu AM, Zhang JY, et al. Prognostic significance of long non-coding RNA MALAT-1 in various human carcinomas: a meta-analysis. Genet Mol Res. 2016;29(1),e15.
Crossref Google Scholar
30

Li C, Chen J, Zhang K, et al. Progress and prospects of long noncoding RNAs (lncRNAs) in hepatocellular carcinoma. Cell Physiol Biochem. 2015;36(2):423-434.
Crossref Google Scholar
31

Sun Lin, Guo Yujie, Peng He, et al. Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. Genes Dis. 2019;6(2):147-158.
Crossref Google Scholar
32

Ouyang T, Zhang Y, Tang S, et al. Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma. Exp Mol Pathol. 2019;111,e104321.
Crossref Google Scholar
33

Yu C, Zhang F. LncRNA AC009022.1 enhances colorectal cancer cells proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR-497-5p. J Cell Biochem. 2020;121(2):1934-1944.
Crossref Google Scholar
34

Peng X, Wei F, Hu X. Long noncoding RNA DLGAP1-AS1 promotes cell proliferation in hepatocellular carcinoma via sequestering miR-486-5p. J Cell Biochem. 2020;121(2):1953-1962.
Crossref Google Scholar
35

Thomas PB, Seim I, Jeffery PL, et al. The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth. Int J Oncol. 2019;55(6):1223-1236.
Crossref Google Scholar
36

Zhang X, Gong J, Lu J, et al. Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1. Am J Transl Res. 2019;11(9):6075-6083.
Google Scholar
37

Zheng S, Lin F, Zhang M, et al. Long non-coding RNA AK001058 regulates tumor growth and angiogenesis in colorectal cancer via methylation of ADAMTS12. Am J Transl Res. 2019;11(9):6117-6123.
Google Scholar
38

Li H, Han Q, Chen Y, et al. Upregulation of the long non-coding RNA FOXD2-AS1 is correlated with tumor progression and metastasis in papillary thyroid cancer. Am J Transl Res. 2019;11(9):5457-5471.
Google Scholar
39

Zhang H, Lu Y, Wu J, et al. LINC00460 hypomethylation promotes metastasis in colorectal carcinoma. Front Genet. 2019;30(10),e880.
Crossref Google Scholar
40

Hu X, Li Q, Zhang J, et al. The long noncoding RNA LINC00908 facilitates hepatocellular carcinoma progression via interaction with Sox-4. Cancer Manag Res. 2019;11:8789-8797.
Crossref Google Scholar
41

Chang QQ, Chen CY, Chen Z, et al. LncRNA PVT1 promotes proliferation and invasion through enhancing Smad3 expression by sponging miR-140-5p in cervical cancer. Radiol Oncol. 2019;53(4):443-452.
Crossref Google Scholar
42

Rossi T, Pistoni M, Sancisi V, et al. RAIN is a novel Enhancer-associated lncRNA that controls RUNX2 expression and promotes breast and thyroid cancer. Mol Cancer Res. 2020;18(1):140-152.
Crossref Google Scholar
43

Qiao K, Ning S, Wan L, et al. LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway. J Exp Clin Cancer Res. 2019;38(1),e418.
Crossref Google Scholar
44

Wang Y, Jiang F, Xiong Y, et al. LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15. Life Sci. 2019;11,e116936.
Crossref Google Scholar
45

Wang ZY, Duan Y, Wang P. SP1-mediated upregulation of lncRNA SNHG4 functions as a ceRNA for miR-377 to facilitate prostate cancer progression through regulation of ZIC5. J Cell Physiol. 2020;235(4):3916-3927.
Crossref Google Scholar
46

Wo Q, Zhang D, Hu L, et al. Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis. Biochem Biophys Res Commun. 2019;520(3):586-593.
Crossref Google Scholar
47

Lou C, Zhao J, Gu Y, et al. LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway. J Cell Physiol. 2020;235(4):3928-3938.
Crossref Google Scholar
48

Feng L, Li J, Li F, et al. Long noncoding RNA VCAN-AS1 contributes to the progression of gastric cancer via regulating p53 expression. J Cell Physiol. 2020;1235(5):4388-4398.
Crossref Google Scholar
49

Fan J, Zhang J, Huang S, Li P. lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis. Biochem Biophys Res Commun. 2020;521(1):196-203.
Crossref Google Scholar
50

Zhao Y, Wang N, Zhang X, et al. LncRNA ZEB1-AS1 down-regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma. J Cell Mol Med. 2019;23(12):8206-8218.
Crossref Google Scholar
51

Zhao B, Cao P, Hu S, et al. LncRNA-NBAT-1 modulates esophageal cancer proliferation via PKM2. Am J Transl Res. 2019;11(9):5978-5987.
Google Scholar
52

Wang W, Xia S, Zhan W, et al. The long non-coding RNA ENST00000489676 influences papillary thyroid cancer cell proliferation and invasion through regulating MiR-922. J Cancer. 2019;10(22):5434-5446.
Crossref Google Scholar
53

Li QY, Yang K, Liu FG, et al. Long noncoding RNA CASC2c inhibited cell proliferation in hepatocellular carcinoma by inactivated ERK1/2 and Wnt/β-catenin signaling pathway. Clin Transl Oncol. 2020;22(3):302-310.
Crossref Google Scholar
54

Ni W, Yao S, Zhou Y, et al. Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3. Mol Cancer. 2019;18(1),e143.
Crossref Google Scholar
55

Liu D, Wu K, Yang Y, et al. Long noncoding RNA ADAMTS9-AS2 suppresses the progression of esophageal cancer by mediating CDH3 promoter methylation. Mol Carcinog. 2020;59(1):32-44.
Crossref Google Scholar
56

Tang C, Wang Y, Zhang L, et al. Identification of novel LncRNA targeting Smad2/PKCα signal pathway to negatively regulate malignant progression of glioblastoma. J Cell Physiol. 2020;235(4):3835-3848.
Crossref Google Scholar
57

Yokoyama Y, Sakatani T, Wada R, et al. In vitro and in vivo studies on the association of long non-coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5-fluorouracil in rectal cancer. Int J Oncol. 2019;55(6):1361-1371.
Crossref Google Scholar
58

Yan Y, Xu Z, Chen X, et al. Novel function of lncRNA ADAMTS9-AS2 in promoting temozolomide resistance in glioblastoma via upregulating the FUS/MDM2 ubiquitination Axis. Front Cell Dev Biol. 2019;7,e217.
Crossref Google Scholar
59

Wang JJ, Huang YQ, Song W, et al. Comprehensive analysis of the lncRNA-associated competing endogenous RNA network in breast cancer. Oncol Rep. 2019;42(6):2572-2582.
Crossref Google Scholar
60

Bermúdez M, Aguilar-Medina M, Lizárraga-Verdugo E, et al. LncRNAs as regulators of autophagy and drug resistance in colorectal cancer. Front Oncol. 2019;9,e1008.
Crossref Google Scholar
61

Lin S, Zhang R, An X, et al. LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells. Oncogenesis. 2019;8(11),e60.
Crossref Google Scholar
62

Miao Y, Fan R, Chen L, et al. Clinical significance of long non- coding RNA MALAT1 expression in tissue and serum of breast cancer. Ann Clin Lab Sci. 2016;46(4):418-424.
Google Scholar
63

Avazpour N, Hajjari M, Tahmasebi Birgani M, et al. HOTAIR: a promising long non-coding RNA with potential role in breast invasive carcinoma. Front Genet. 2017;8,e170.
Crossref Google Scholar
64

Xu W, Zhou G, Wang H, et al. Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer. Int J Cancer. 2020;146(10):2901-2912.
Crossref Google Scholar
65

Tamang S, Acharya V, Roy D, et al. SNHG12: an LncRNA as a potential therapeutic target and biomarker for human cancer. Front Oncol. 2019;9,e901.
Crossref Google Scholar
66

Pan L, Liang W, Gu J, et al. Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells. Oncotarget. 2017;9(2):1915-1930.
Crossref Google Scholar
67

Li S, Li J, Chen C, Zhang R, Wang K. Pan-cancer analysis of long non-coding RNA NEAT1 in various cancers. Genes Dis. 2018;5(1):27-35.
Crossref Google Scholar
68

He RZ, Luo DX, Mo YY, et al. Emerging roles of lncRNAs in the post-transcriptional regulation in cancer. Genes Dis. 2019;6(1):6-15.
Crossref Google Scholar
69

Liang WQ, Zeng D, Chen CF, et al. Long noncoding RNA H19 is a critical oncogenic driver and contributes to epithelial-mesenchymal transition in papillary thyroid carcinoma. Cancer Manag Res. 2019;11:2059-2072.
Crossref Google Scholar
70

Wang P, Liu G, Xu W, Liu H, Bu Q, Sun D. Long noncoding RNA H19 inhibits cell viability, migration, and invasion via downregulation of IRS-1 in thyroid cancer cells. Technol Cancer Res Treat. 2017;16(6):1102-1112.
Crossref Google Scholar
71

Wu ZR, Yan L, Liu YT, et al. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours. Nat Commun. 2018;9(1),e4624.
Crossref Google Scholar
72

Gao H, Hao G, Sun Y, Li L, Wang Y. Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process. Onco Targets Ther. 2018;11:8001-8012.
Crossref Google Scholar
73

Gao LM, Xu SF, Zheng Y, et al. Long non-coding RNA H19 is responsible for the progression of lung adenocarcinoma by mediating methylation-dependent repression of CDH1 promoter. J Cell Mol Med. 2019;23(9):6411-6428.
Crossref Google Scholar
74

Gugnoni M, Ciarrocchi A. Long noncoding RNA and epithelial mesenchymal transition in cancer. Int J Mol Sci. 2019;20(8),e1924.
Crossref Google Scholar
75

Feng GS. Conflicting roles of molecules in epatocarcino- genesis: paradigm or paradox. Cancer Cell. 2012;21(2):150-154.
Crossref Google Scholar
76

Yang N, Ekanem NR, Sakyi CA, et al. Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnostics. Adv Drug Deliv Rev. 2015;81:62-74.
Crossref Google Scholar
77

Maluccio M, Covey A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 2012;62(6),e394.
Crossref Google Scholar
78

Mehra M, Chauhan R. Long noncoding RNAs as a key player in hepatocellular carcinoma. Biomark Cancer. 2017;9.e1179299X1 7737301.
Crossref Google Scholar
79

Lanzafame M, Bianco G, Terracciano LM, et al. The role of long non-coding RNAs in hepatocarcinogenesis. Int J Mol Sci. 2018;19(3),e682.
Crossref Google Scholar
80

Qiu L, Tang Q, Li G, et al. Long non-coding RNAs as biomarkers and therapeutic targets: recent insights into hepatocellular carcinoma. Life Sci. 2017;191:273-282.
Crossref Google Scholar
81

He Y, Meng XM, Huang C, et al. Long noncoding RNAs: novel insights into hepatocelluar carcinoma. Cancer Lett. 2014;344(1):20-27.
Crossref Google Scholar
82

Cao MR, Han ZP, Liu JM, et al. Bioinformatic analysis and prediction of the function and regulatory network of long non-coding RNAs in hepatocellular carcinoma. Oncol Lett. 2018;15(5):7783-7793.
Crossref Google Scholar
83

Gramantieri L, Baglioni M, Fornari F, et al. LncRNAs as novel players in hepatocellular carcinoma recurrence. Oncotarget. 2018;9(80):35085-35099.
Crossref Google Scholar
84

Guerrieri F. Long non-coding RNAs era in liver cancer. World J Hepatol. 2015;7(16):1971-1973.
Crossref Google Scholar
85

Wang BG, Lv Z, Ding HX, et al. The association of lncRNA-HULC polymorphisms with hepatocellular cancer risk and prognosis. Gene. 2018;670:148-154.
Crossref Google Scholar
86

Xiong H, Li B, He J, et al. lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein. Biochem Biophys Res Commun. 2017;490(3):693-699.
Crossref Google Scholar
87

Sonohara F, Sugimoto H, Hayashi M, et al. Prognostic value of long non-coding RNA HULC and MALAT1 following the curative resection of hepatocellular carcinoma. Sci Rep. 2017;7(1),e16142.
Crossref Google Scholar
88

Wang J, Liu X, Wu H, et al. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res. 2010;38(16):5366-5383.
Crossref Google Scholar
89

Chi Y, Wang D, Wang J, et al. Long non-coding RNA in the pathogenesis of cancers. Cells. 2019;8(9),e1015.
Crossref Google Scholar
90

Wu Y, Xiong Q, Li S, Yang X, Ge F. Integrated proteomic and transcriptomic analysis reveals long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) promotes hepatocellular carcinoma cell proliferation by regulating opioid growth factor receptor (OGFr). Mol Cell Proteom. 2018;17(1):146-159.
Crossref Google Scholar
91

Cheng D, Deng J, Zhang B, et al. LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. EBioMedicine. 2018;36:159-170.
Crossref Google Scholar
92

Yao Y, Li J, Wang L. Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers. Int J Mol Sci. 2014;15(10):18985-18999.
Crossref Google Scholar
93

Wu L, Zhang L, Zheng S. Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma. Oncol Lett. 2017;14(2):1233-1239.
Crossref Google Scholar
94

Li H, An J, Wu M, Zheng Q, et al. LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget. 2015;6(29):27847-27864.
Crossref Google Scholar
95

Yang L, Peng X, Li Y, et al. Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma. Mol Cancer. 2019;18(1),e78.
Crossref Google Scholar
96

Chen Z, Yu W, Zhou Q, et al. A novel lncRNA IHS promotes tumor proliferation and metastasis in HCC by regulating the ERK- and AKT/GSK-3β-Signaling pathways. Mol Ther Nucleic Acids. 2019;16:707-720.
Crossref Google Scholar
97

Wang H, Huo X, Yang XR, et al. STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 2017;16,e136.
Crossref Google Scholar
98

Pan W, Li W, Zhao J, et al. lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway. Mol Oncol. 2019;13(10):2246-2258.
Crossref Google Scholar
99

Wang CZ, Yan GX, Dong DS, et al. LncRNA-ATB promotes autophagy by activating Yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma. World J Gastroenterol. 2019;25(35):5310-5322.
Crossref Google Scholar
100

Xiao Li, Qi Zhao, Qi Jianni, et al. lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma. Int J Oncol. 2018;53(2):551-566.
Google Scholar
101

Ding LJ, Li Y, Wang SD, et al. Long noncoding RNA lncCAMTA1 promotes proliferation and cancer stem cell-like properties of liver cancer by inhibiting CAMTA1. Int J Mol Sci. 2016;17(10),e1617.
Crossref Google Scholar
102

Dai W, Dai JL, Tang MH, et al. lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/histone deacetylase 2 axis. World J Gastroenterol. 2019;25(38):5789-5799.
Crossref Google Scholar
103

Hu X, Li Q, Zhang J. The long noncoding RNA LINC00908 facilitates hepatocellular carcinoma progression via interaction with Sox-4. Cancer Manag Res. 2019;11:8789-8797.
Crossref Google Scholar
104

Wang Y, Yang L, Chen T, et al. A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 2019;18,e28.
Crossref Google Scholar
105

Pan W, Zhang N, Liu W, et al. The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8. J Biol Chem. 2018;293(44):17154-17165.
Crossref Google Scholar
106

Hu J, Song C, Duan B, et al. LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma. Oncotarget. 2017;8(58):97835-97850.
Crossref Google Scholar
107

Wen N, Zhang Y, Zhan Z, et al. A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1. J Hematol Oncol. 2017;10(1),e91.
Crossref Google Scholar
108

Yu S, Li N, Huang Z, et al. A novel lncRNA, TCONS_00006195, represses hepatocellular carcinoma progression by inhibiting enzymatic activity of ENO1. Cell Death Dis. 2018;9(12),e1184.
Crossref Google Scholar
109

Wang YG, Wang T, Shi M, et al. Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. J Exp Clin Cancer Res. 2019;38(1),e153.
Crossref Google Scholar
110

Yu Z, Zhao H, Feng X, et al. Long non-coding RNA FENDRR acts as a miR-423-5p sponge to suppress the treg-mediated immune escape of hepatocellular carcinoma cells. Mol Ther Nucleic Acids. 2019;17:516-529.
Crossref Google Scholar
111

Ge Z, Cheng Z, Yang X, et al. Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma. Cancer Sci. 2017;108(4):653-662.
Crossref Google Scholar
112

Chen F, Li Y, Li M, Wang L, et al. Long noncoding RNA GAS5 inhibits metastasis by targeting miR-182/ANGPTL1 in hepatocellular carcinoma. Am J Cancer Res. 2019;9(1):108-121.
Google Scholar
113

Yan S, Tang Z, Chen K, et al. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. J Exp Clin Cancer Res. 2018;37(1),e214.
Crossref Google Scholar
114

Wu Y, Zhou Y, Huan L, et al. LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells. Cancer Sci. 2019;110(3):973-984.
Crossref Google Scholar
115

Wu Y, Wang PS, Wang BG, et al. Genomewide identification of a novel six-LncRNA signature to improve prognosis prediction in resectable hepatocellular carcinoma. Cancer Med. 2018;7(12):6219-6233.
Crossref Google Scholar
116

Li G, Zhang H, Wan X, et al. Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma. BioMed Res Int. 2014;2014, e780521.
Crossref Google Scholar
117

Wang H, Liang L, Dong Q, et al. Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma. Theranostics. 2018;8(10):2814-2829.
Crossref Google Scholar
118

Zhang J, Zhang D, Zhao Q, Qi J, Li X, Qin C. A distinctively expressed long noncoding RNA, RP11-466I1.1, may serve as a prognostic biomarker in hepatocellular carcinoma. Cancer Med. 2018;7(7):2960-2968.
Crossref Google Scholar
119

Yu J, Han J, Zhang J, et al. The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis. Medicine (Baltim). 2016;95(31),e4436.
Crossref Google Scholar
120

Zheng ZK, Pang C, Yang Y, Duan Q, Zhang J, Liu WC. Serum long noncoding RNA urothelial carcinoma-associated 1: a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. J Int Med Res. 2018;46(1):348-356.
Crossref Google Scholar
121

Wang ZF, Hu R, Pang JM, et al. Serum long noncoding RNA LRB1 as a potential biomarker for predicting the diagnosis and prognosis of human hepatocellular carcinoma. Oncol Lett. 2018;16(2):1593-1601.
Crossref Google Scholar
122

Li G, Shi H, Wang X, et al. Identification of diagnostic long non-coding RNA biomarkers in patients with hepatocellular carcinoma. Mol Med Rep. 2019;20(2):1121-1130.
Crossref Google Scholar
123

Luo T, Chen M, Zhao Y, et al. Macrophage-associated lncRNA ELMO1-AS1: a novel therapeutic target and prognostic biomarker for hepatocellular carcinoma. OncoTargets Ther. 2019;12:6203-6216.
Crossref Google Scholar
124

Zhang Q, Matsuura K, Kleiner DE, Zamboni F, Alter HJ, Farci P. Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology. J Transl Med. 2016;14,e328.
Crossref Google Scholar
125

Zhang Y, Huang JC, Cai KT, et al. Long non-coding RNA HOTTIP promotes hepatocellular carcinoma tumorigenesis and development: a comprehensive investigation based on bioinformatics, qRT-PCR and meta-analysis of 393 cases. Int J Oncol. 2017;51(6):1705-1721.
Crossref Google Scholar
126

Zeng T, Wang D, Chen J, et al. AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p. Exp Cell Res. 2018;363(1):129-139.
Crossref Google Scholar
127

Wang JY, Yang Y, Ma Y, et al. Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma. Biomed Pharmacother. 2020;121,e109627.
Crossref Google Scholar
128

Yan S, Tang Z, Chen K, et al. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. J Exp Clin Cancer Res. 2018;37(1),e214.
Crossref Google Scholar
Genes & Diseases
Volume 8 Issue 2,
March 2021
Pages 157-167
DOI: 10.1016/j.gendis.2019.12.013
Cite this article:
Wang D, Chen F, Zeng T, et al. Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma. Genes & Diseases, 2021, 8(2): 157-167. https://doi.org/10.1016/j.gendis.2019.12.013

223

Views

3

Downloads

8

Crossref

N/A

Web of Science

8

Scopus

1

CSCD

Altmetrics
Received: 20 November 2019
Revised: 16 December 2019
Accepted: 31 December 2019
Published: 08 January 2020
© 2020, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return