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Review Article | Open Access

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

Mohammad Reza Zinatizadeha,,†( ), Bettina Schockb,,†, Ghanbar Mahmoodi Chalbatanic,d, Peyman Kheirandish Zarandia, Seyed Amir Jalalie, Seyed Rouhollah Mirid,( )
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1336616357, Iran
Centre for Experimental Medicine, Queen’s University Belfast, Belfast, BT7 1NN, United Kingdom
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1336616357, Iran
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, 1336616357, Iran
Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1336616357, Iran

† These authors contributed equally to this study.]]>

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Abstract

The nuclear factor kappa B (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the expression of important regulatory genes such as immunity, inflammation, death, and cell proliferation. NF-kB protein is located in the cytoplasm, and can be activated by various cellular stimuli. There are two pathways for NF-kB activation, as the canonical and non-canonical pathways, which require complex molecular interactions with adapter proteins and phosphorylation and ubiquitinase enzymes. Accordingly, this increases NF-kB translocation in the nucleus and regulates gene expression. In this study, the concepts that emerge in different cellular systems allow the design of NF-kB function in humans. This would not only allow the development for rare diseases associated with NF-kB, but would also be used as a source of useful information to eliminate widespread consequences such as cancer or inflammatory/immune diseases.

Keywords

InflammationCancerSignalingImmunityNF-κB

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Genes & Diseases
Volume 8 Issue 3,
May 2021
Pages 287-297
DOI: 10.1016/j.gendis.2020.06.005
Cite this article:
Zinatizadeh MR, Schock B, Chalbatani GM, et al. The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases. Genes & Diseases, 2021, 8(3): 287-297. https://doi.org/10.1016/j.gendis.2020.06.005

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Received: 16 November 2019
Revised: 26 May 2020
Accepted: 12 June 2020
Published: 18 July 2020
© 2020, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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