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Review Article | Open Access

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Xi Liua,cJimin XubJia Zhoub( )Qiang Shena( )
Department of Genetics, Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA
Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX, 77555, USA

c Current address: Departments of Hepatopancreatobiliary Surgery, Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan 650101, PR China]]>

Show Author Information

Abstract

Cancer is one of the diseases with high morbidity and mortality on a global scale. Chemotherapy remains the primary treatment option for most cancer patients, including patients with progressive, metastatic, and recurrent diseases. To date, hundreds of chemotherapy drugs are used to treat various cancers, however, the anti-cancer efficacy and outcomes are largely hampered by chemotherapy-associated toxicity and acquired therapeutic resistance. The natural product (NP) oridonin has been extensively studied for its anti-cancer efficacy. More recently, oridonin has been shown to overcome drug resistance through multiple mechanisms, with yet-to-be-defined bona fide targets. Hundreds of oridonin derivative analogs (oridonalogs) have been synthesized and screened for improved potency, bioavailability, and other drug properties. Particularly, many of these oridonalogs have been tested against oridonin for tumor growth inhibition, potential for overcoming therapeutic resistance, and immunity modulation. This concise review seeks to summarize the advances in this field in light of identifying clinical-trial level drug candidates with the promise for treating progressive cancers and reversing chemoresistance.

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Genes & Diseases
Pages 448-462
Cite this article:
Liu X, Xu J, Zhou J, et al. Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance. Genes & Diseases, 2021, 8(4): 448-462. https://doi.org/10.1016/j.gendis.2020.06.010

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Received: 15 May 2020
Revised: 23 June 2020
Accepted: 29 June 2020
Published: 05 July 2020
© 2020, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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