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Review Article | Open Access

LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

Fangqi Xiaa, Yaqi Wanga, Mengzhen Xuea, Leiqi Zhua, Dengke Jiaa, Yue Shia, Yan Gaoa, Luoying Lia, Yuanyang Lia, Silong Chena, Guangfu Xua, Ding Yuana,b( ), Chengfu Yuana,b,c( )
College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China
Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang, Hubei 443002, PR China
Hubei Key Laboratory of Tumour Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei 443002, PR China
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Abstract

Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years, the role and development of lncRNAs have aroused the rising attention of researchers. To be specific, KCNQ1OT1, the KCNQ1 opposite strand/antisense transcript 1, is clearly classified as a regulatory ncRNA. KCNQ1OT1 is capable of interacting with miRNAs, RNAs and proteins, thereby affecting gene expression and various cell functions (e.g., cell proliferation, migration, epithelial–mesenchymal transition (EMT), apoptosis, viability, autophagy and inflammation). KCNQ1OT1 is dysregulated in a wide range of human diseases (e.g., cardiovascular disease, cancer, diabetes, osteoarthritis, osteoporosis and cataract), and it is speculated to act as a therapeutic target for treating various human diseases. On the whole, this review aims to explore the biological functions, underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases.

Keywords

Cell functionsHuman diseasesKCNQ1OT1Long non–coding RNARegulatory ncRNA

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Genes & Diseases
Volume 9 Issue 6,
November 2022
Pages 1556-1565
DOI: 10.1016/j.gendis.2021.07.003
Cite this article:
Xia F, Wang Y, Xue M, et al. LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases. Genes & Diseases, 2022, 9(6): 1556-1565. https://doi.org/10.1016/j.gendis.2021.07.003

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Received: 11 April 2021
Revised: 13 June 2021
Accepted: 28 July 2021
Published: 16 August 2021
© 2021, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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