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Review Article | Open Access

Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Wencheng Kong, Guang Yin, Sixin Zheng, Xinchun Liu, Akao Zhu, Panpan Yu, Jian Zhang, Yuqiang Shan, Rongchao Ying( ), Huicheng Jin
Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China

Peer review under responsibility of Chongqing Medical University.

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Abstract

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies.

Keywords

Gastric cancerExpressionHOTAIR regulationRegulatory pathways

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Genes & Diseases
Volume 9 Issue 5,
September 2022
Pages 1269-1280
DOI: 10.1016/j.gendis.2021.07.006
Cite this article:
Kong W, Yin G, Zheng S, et al. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer. Genes & Diseases, 2022, 9(5): 1269-1280. https://doi.org/10.1016/j.gendis.2021.07.006

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Received: 02 November 2020
Revised: 21 June 2021
Accepted: 06 July 2021
Published: 21 August 2021
© 2021, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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