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Rapid Communication | Open Access

Targeting BMI1 mitigates chemoresistance in ovarian cancer

Anindya DeyaShailendra Kumar Dhar DwivediaLin WangbMd Nazir Hossenc,dFiifi Neizer-AshuneMagdalena BieniaszbPriyabrata Mukherjeec,fJohn D. BairdgMarla WeetallgResham Bhattacharyaa,e,f( )
Department of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Department of Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA 95757, USA
Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
PTC Therapeutics, Inc, South Plainfield, NJ 07080, USA

Peer review under responsibility of Chongqing Medical University.

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References

1

Kim S, Han Y, Kim SI, Kim HS, Kim SJ, Song YS. Tumor evolution and chemoresistance in ovarian cancer. NPJ Precis Oncol. 2018;2:20.

2

Wang E, Bhattacharyya S, Szabolcs A, et al. Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer. PLoS One. 2011;6(3):e17918.

3

Banerjee Mustafi S, Chakraborty PK, Naz S, et al. MDR1 mediated chemoresistance: BMI1 and TIP60 in action. Biochim Biophys Acta. 2016;1859(8):983-993.

4

Bhattacharya R, Nicoloso M, Arvizo R, et al. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res. 2009;69(23):9090-9095.

5

Dey A, Xiong X, Crim A, et al. Evaluating the mechanism and therapeutic potential of PTC-028, a novel inhibitor of BMI-1 function in ovarian cancer. Mol Cancer Therapeut. 2018;17(1):39-49.

Genes & Diseases
Pages 1415-1418
Cite this article:
Dey A, Dhar Dwivedi SK, Wang L, et al. Targeting BMI1 mitigates chemoresistance in ovarian cancer. Genes & Diseases, 2022, 9(6): 1415-1418. https://doi.org/10.1016/j.gendis.2022.02.006

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Received: 22 December 2021
Published: 18 March 2022
© 2022, Chongqing Medical University.

This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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