AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (4 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article | Open Access

Therapeutic potential for targeting Annexin A1 in fibrotic diseases

Zhibin Yana, Xurui Chenga, Tao Wanga, Xiangyu Honga, Gang Shaob, Caiyun Fua( )
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR China
Department of Oncology, No. 903 Hospital of PLA Joint Logistic Support Force, Xi Hu Affiliated Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310013, PR China
Show Author Information

Abstract

Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis. However, the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive, and even the functions of Annexin A1 in fibrotic diseases are still paradoxical. This review focuses on the roles of Annexin A1 in the development of fibrosis of lung, liver, heart, and other tissues, with emphasis on the therapy potential of Annexin A1 in fibrosis, and presents future research interests and directions in fibrotic diseases.

Keywords

Annexin A1Anti-inflammatoryFibrosisFibrotic diseasesSequence alignment

References

1

Rosenbloom J, Macarak E, Piera-Velazquez S, Jimenez SA. Human fibrotic diseases: current challenges in fibrosis research. Methods Mol Biol. 2017;1627: 1-23.
Crossref Google Scholar
2

Zhu H, Zhao H, Xu S, et al. Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis. Pharmacol Res. 2021;174: 105926.
Crossref Google Scholar
3

Peng L, Agogo GO, Guo J, Yan M. Substance P and fibrotic diseases. Neuropeptides. 2019;76: 101941.
Crossref Google Scholar
4

Distler JHW, Györfi AH, Ramanujam M, Whitfield ML, Königshoff M, Lafyatis R. Shared and distinct mechanisms of fibrosis. Nat Rev Rheumatol. 2019;15(12): 705-730.
Crossref Google Scholar
5

Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012;18(7): 1028-1040.
Crossref Google Scholar
6

Wang E, He X, Zeng M. The role of S1P and the related signaling pathway in the development of tissue fibrosis. Front Pharmacol. 2019;9: 1504.
Crossref Google Scholar
7

Hu HH, Chen DQ, Wang YN, et al. New insights into TGF-β/Smad signaling in tissue fibrosis. Chem Biol Interact. 2018;292: 76-83.
Crossref Google Scholar
8

Shihata WA, Putra MRA, Chin-Dusting JPF. Is there a potential therapeutic role for caveolin-1 in fibrosis? Front Pharmacol. 2017;8: 567.
Crossref Google Scholar
9

Stone RC, Chen V, Burgess J, Pannu S, Tomic-Canic M. Genomics of human fibrotic diseases: disordered wound healing response. Int J Mol Sci. 2020;21(22): 8590.
Crossref Google Scholar
10

Wu L, Liu C, Chang DY, et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021;100(1): 107-121.
Crossref Google Scholar
11

Qin CX, Rosli S, Deo M, et al. Cardioprotective actions of the annexin-A1 N-terminal peptide, Ac2-26, against myocardial infarction. Front Pharmacol. 2019;10: 269.
Crossref Google Scholar
12

Creutz CE, Pazoles CJ, Pollard HB. Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J Biol Chem. 1978;253(8): 2858-2866.
Crossref Google Scholar
13

Xi Y, Ju R, Wang Y. Roles of Annexin A protein family in autophagy regulation and therapy. Biomed Pharmacother. 2020;130: 110591.
Crossref Google Scholar
14

Gerke V, Moss SE. Annexins: from structure to function. Physiol Rev. 2002;82(2): 331-371.
Crossref Google Scholar
15

Laohavisit A, Davies JM. Annexins. New Phytol. . 2011;189(1): 40-53.
Crossref Google Scholar
16

Mirsaeidi M, Gidfar S, Vu A, Schraufnagel D. Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis. J Transl Med. 2016;14: 89.
Crossref Google Scholar
17

Grewal T, Rentero C, Enrich C, Wahba M, Raabe CA, Rescher U. Annexin animal models-from fundamental principles to translational research. Int J Mol Sci. 2021;22(7): 3439.
Crossref Google Scholar
18

Bendix PM, Simonsen AC, Florentsen CD, et al. Interdisciplinary synergy to reveal mechanisms of annexin-mediated plasma membrane shaping and repair. Cells. 2020;9(4): 1029.
Crossref Google Scholar
19

Foo SL, Yap G, Cui J, Lim LHK. Annexin-A1 - a blessing or a curse in cancer? Trends Mol Med. 2019;25(4): 315-327.
Crossref Google Scholar
20

Boudhraa Z, Bouchon B, Viallard C, D'Incan M, Degoul F. Annexin A1 localization and its relevance to cancer. Clin Sci (Lond). 2016;130(4): 205-220.
Crossref Google Scholar
21

D'Acquisto F, Piras G, Rattazzi L. Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts. Biochem Pharmacol. 2013;85(9): 1213-1218.
Crossref Google Scholar
22

D'Acunto CW, Gbelcova H, Festa M, Ruml T. The complex understanding of Annexin A1 phosphorylation. Cell Signal. 2014;26(1): 173-178.
Crossref Google Scholar
23

McArthur S, Yazid S, Christian H, et al. Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J. 2009;23(11): 4000-4010.
Crossref Google Scholar
24

Sugimoto MA, Vago JP, Teixeira MM, Sousa LP. Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance. J Immunol Res. 2016;2016: 8239258.
Crossref Google Scholar
25

Sheikh MH, Solito E. Annexin A1: uncovering the many talents of an old protein. Int J Mol Sci. 2018;19(4): 1045.
Crossref Google Scholar
26

Bruschi M, Petretto A, Vaglio A, Santucci L, Candiano G, Ghiggeri GM. Annexin A1 and autoimmunity: from basic science to clinical applications. Int J Mol Sci. 2018;19(5): 1348.
Crossref Google Scholar
27

Qin C, Yang YH, May L, et al. Cardioprotective potential of annexin-A1 mimetics in myocardial infarction. Pharmacol Ther. 2015;148: 47-65.
Crossref Google Scholar
28

Lim LH, Solito E, Russo-Marie F, Flower RJ, Perretti M. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci USA. 1998;95(24): 14535-14539.
Crossref Google Scholar
29

Walther A, Riehemann K, Gerke V. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5): 831-840.
Crossref Google Scholar
30

Hayhoe RP, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M. Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood. 2006;107(5): 2123-2130.
Crossref Google Scholar
31

Strausbaugh HJ, Rosen SD. A potential role for annexin 1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells. J Immunol. 2001;166(10): 6294-6300.
Crossref Google Scholar
32

Solito E, Romero IA, Marullo S, Russo-Marie F, Weksler BB. Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. J Immunol. 2000;165(3): 1573-1581.
Crossref Google Scholar
33

Filep JG, El Kebir D. Neutrophil apoptosis: a target for enhancing the resolution of inflammation. J Cell Biochem. 2009;108(5): 1039-1046.
Crossref Google Scholar
34

Li Y, Cai L, Wang H, et al. Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2. Oncogene. 2011;30(36): 3887-3899.
Crossref Google Scholar
35

Cooray SN, Gobbetti T, Montero-Melendez T, et al. Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci USA. 2013;110(45): 18232-18237.
Crossref Google Scholar
36

Arur S, Uche UE, Rezaul K, et al. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003;4(4): 587-598.
Crossref Google Scholar
37

Scannell M, Flanagan MB, deStefani A, et al. Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. J Immunol. 2007;178(7): 4595-4605.
Crossref Google Scholar
38

Delaney C, Davizon-Castillo P, Allawzi A, et al. Platelet activation contributes to hypoxia-induced inflammation. Am J Physiol Lung Cell Mol Physiol. 2021;320(3): L413-L421.
Crossref Google Scholar
39

Senchenkova EY, Ansari J, Becker F, et al. Novel role for the AnxA1-Fpr2/ALX signaling axis as a key regulator of platelet function to promote resolution of inflammation. Circulation. 2019;140(4): 319-335.
Crossref Google Scholar
40

Lima KM, Vago JP, Caux TR, et al. The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. J Biol Chem. 2017;292(33): 13758-13773.
Crossref Google Scholar
41

Sanches JM, Branco LM, Duarte GHB, et al. Annexin A1 regulates NLRP3 inflammasome activation and modifies lipid release profile in isolated peritoneal macrophages. Cells. 2020;9(4): 926.
Crossref Google Scholar
42

Sakaguchi M, Murata H, Sonegawa H, et al. Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells. J Biol Chem. 2007;282(49): 35679-35686.
Crossref Google Scholar
43

Han PF, Che XD, Li HZ, Gao YY, Wei XC, Li PC. Annexin A1 involved in the regulation of inflammation and cell signaling pathways. Chin J Traumatol. 2020;23(2): 96-101.
Crossref Google Scholar
44

Rossi AG, Sawatzky DA, Walker A, et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med. 2006;12(9): 1056-1064.
Crossref Google Scholar
45

Filep JG. Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution. Proc Natl Acad Sci USA. 2013;110(45): 18033-18034.
Crossref Google Scholar
46

Mertz PM, DeWitt DL, Stetler-Stevenson WG, Wahl LM. Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production. J Biol Chem. 1994;269(33): 21322-21329.
Crossref Google Scholar
47

Ferlazzo V, D'Agostino P, Milano S, et al. Anti-inflammatory effects of annexin-1: stimulation of IL-10 release and inhibition of nitric oxide synthesis. Int Immunopharmacol. 2003;3(10–11): 1363-1369.
Crossref Google Scholar
48

Yap GLR, Sachaphibulkij K, Foo SL, Cui J, Fairhurst AM, Lim LHK. Annexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3-IFNAR-STAT1-IFIT1 pathway in A549 lung epithelial cells. Cell Death Dis. 2020;11(6): 463.
Crossref Google Scholar
49

Li X, Xia Q, Mao M, et al. Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy. Sci Adv. 2021;7(4): eabc5539.
Crossref Google Scholar
50

Swa HL, Blackstock WP, Lim LH, Gunaratne J. Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration. Mol Cell Proteomics. 2012;11(8): 381-393.
Crossref Google Scholar
51

Xia W, Zhu J, Wang X, et al. ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway. FASEB J. 2020;34(10): 13993-14005.
Crossref Google Scholar
52

Li CY, Cai JH, Tsai JJP, Wang CCN. Identification of hub genes associated with development of head and neck squamous cell carcinoma by integrated bioinformatics analysis. Front Oncol. 2020;10: 681.
Crossref Google Scholar
53

Xia Q, Li X, Zhou H, Zheng L, Shi J. S100A11 protects against neuronal cell apoptosis induced by cerebral ischemia via inhibiting the nuclear translocation of annexin A1. Cell Death Dis. 2018;9(6): 657.
Crossref Google Scholar
54

Chen L, Yuan Y, Kar S, et al. PPARγ ligand-induced Annexin A1 expression determines chemotherapy response via deubiquitination of death domain kinase RIP in triple-negative breast cancers. Mol Cancer Ther. 2017;16(11): 2528-2542.
Crossref Google Scholar
55

Zhu JF, Huang W, Yi HM, et al. Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation. Cell Death Dis. 2018;9(12): 1154.
Crossref Google Scholar
56

Bai F, Zhang P, Fu Y, et al. Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. J Immunother Cancer. 2020;8(1): e000169.
Crossref Google Scholar
57

Zhou C, Lin Z, Cao H, et al. Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovasc Res. 2022;118(6): 1564-1582.
Crossref Google Scholar
58

Purvis GSD, Collino M, Loiola RA, et al. Identification of AnnexinA1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes. Front Immunol. 2019;10: 571.
Crossref Google Scholar
59

Henderson NC, Rieder F, Wynn TA. Fibrosis: from mechanisms to medicines. Nature. 2020;587(7835): 555-566.
Crossref Google Scholar
60

Zaiss DMW. Amphiregulin as a driver of tissue fibrosis. Am J Transplant. 2020;20(3): 631-632.
Crossref Google Scholar
61

Piersma B, Hayward MK, Weaver VM. Fibrosis and cancer: a strained relationship. Biochim Biophys Acta Rev Cancer. 2020;1873(2): 188356.
Crossref Google Scholar
62

Parola M, Pinzani M. Pathophysiology of organ and tissue fibrosis. Mol Aspects Med. 2019;65: 1.
Crossref Google Scholar
63

Bensalem N, Ventura AP, Vallée B, et al. Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics. 2005;4(10): 1591-1601.
Crossref Google Scholar
64

Damazo AS, Sampaio AL, Nakata CM, Flower RJ, Perretti M, Oliani SM. Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. BMC Immunol. 2011;12: 59.
Crossref Google Scholar
65

, Burnett AL. Protective effect of annexin-A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat. BJU Int. 2012;110(9): 1346-1351.
Crossref Google Scholar
66

Neymeyer H, Labes R, Reverte V, et al. Activation of annexin A1 signalling in renal fibroblasts exerts antifibrotic effects. Acta Physiol (Oxf). 2015;215(3): 144-158.
Crossref Google Scholar
67

Yu G, Tzouvelekis A, Wang R, et al. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med. 2018;24(1): 39-49.
Crossref Google Scholar
68

Wang D, Yan Z, Bu L, et al. Protective effect of peptide DR8 on bleomycin-induced pulmonary fibrosis by regulating the TGF-β/MAPK signaling pathway and oxidative stress. Toxicol Appl Pharmacol. 2019;382: 114703.
Crossref Google Scholar
69

Luppi F, Kalluri M, Faverio P, Kreuter M, Ferrara G. Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management. Respir Res. 2021;22(1): 109.
Crossref Google Scholar
70

Kurosu K, Takiguchi Y, Okada O, et al. Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis. J Immunol. 2008;181(1): 756-767.
Crossref Google Scholar
71

Jia Y, Morand EF, Song W, Cheng Q, Stewart A, Yang YH. Regulation of lung fibroblast activation by annexin A1. J Cell Physiol. 2013;228(2): 476-484.
Crossref Google Scholar
72

Yang Y, Hu L, Xia H, et al. Resolvin D1 attenuates mechanical stretch-induced pulmonary fibrosis via epithelial-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2019;316(6): L1013-L1024.
Crossref Google Scholar
73

Liu T, De Los Santos FG, Phan SH. The bleomycin model of pulmonary fibrosis. Methods Mol Biol. 2017;1627: 27-42.
Crossref Google Scholar
74

Trentin PG, Ferreira TP, Arantes AC, et al. Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. Br J Pharmacol. 2015;172(12): 3058-3071.
Crossref Google Scholar
75

Lai T, Li Y, Mai Z, et al. Annexin A1 is elevated in patients with COPD and affects lung fibroblast function. Int J Chron Obstruct Pulmon Dis. 2018;13: 473-486.
Crossref Google Scholar
76

Kuppe C, Ibrahim MM, Kranz J, et al. Decoding myofibroblast origins in human kidney fibrosis. Nature. 2021;589(7841): 281-286.
Crossref Google Scholar
77

Djudjaj S, Boor P. Cellular and molecular mechanisms of kidney fibrosis. Mol Aspects Med. 2019;65: 16-36.
Crossref Google Scholar
78

Leaf IA, Duffield JS. What can target kidney fibrosis? Nephrol Dial Transplant. 2017;32(suppl_1): i89-i97.
Crossref Google Scholar
79

Nezu M, Suzuki N. Roles of Nrf2 in protecting the kidney from oxidative damage. Int J Mol Sci. 2020;21(8): 2951.
Crossref Google Scholar
80

Eltoweissy M, Dihazi GH, Müller GA, Asif AR, Dihazi H. Protein DJ-1 and its anti-oxidative stress function play an important role in renal cell mediated response to profibrotic agents. Mol Biosyst. 2016;12(6): 1842-1859.
Crossref Google Scholar
81

Moreno JA, Gomez-Guerrero C, Mas S, et al. Targeting inflammation in diabetic nephropathy: a tale of hope. Expert Opin Investig Drugs. 2018;27(11): 917-930.
Crossref Google Scholar
82

Perucci LO, Sugimoto MA, Gomes KB, Dusse LM, Teixeira MM, Sousa LP. Annexin A1 and specialized proresolving lipid mediators: promoting resolution as a therapeutic strategy in human inflammatory diseases. Expert Opin Ther Targets. 2017;21(9): 879-896.
Crossref Google Scholar
83

Zhang T, Ma C, Zhang Z, Zhang H, Hu H. NF-κB signaling in inflammation and cancer. MedComm. 2021;2(4): 618-653.
Crossref Google Scholar
84

Yuan Y, Zhang F, Wu J, Shao C, Gao Y. Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model. Sci Rep. 2015;5: 9314.
Crossref Google Scholar
85

Li S, Ghoshal S, Sojoodi M, et al. The farnesoid X receptor agonist EDP-305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction. FASEB J. 2019;33(6): 7103-7112.
Crossref Google Scholar
86

Kypreou KP, Kavvadas P, Karamessinis P, et al. Altered expression of calreticulin during the development of fibrosis. Proteomics. 2008;8(12): 2407-2419.
Crossref Google Scholar
87

Zhao SQ, Shen ZC, Gao BF, Han P. microRNA-206 overexpression inhibits epithelial-mesenchymal transition and glomerulosclerosis in rats with chronic kidney disease by inhibiting JAK/STAT signaling pathway. J Cell Biochem. 2019;120(9): 14604-14617.
Crossref Google Scholar
88

Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18(3): 151-166.
Crossref Google Scholar
89

Yan Z, Wang D, An C, et al. The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis. Acta Pharm Sin B. 2021;11(1): 100-111.
Crossref Google Scholar
90

Locatelli I, Sutti S, Jindal A, et al. Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology. 2014;60(2): 531-544.
Crossref Google Scholar
91

Zagoura D, Trohatou O, Makridakis M, et al. Functional secretome analysis reveals Annexin-A1 as important paracrine factor derived from fetal mesenchymal stem cells in hepatic regeneration. EBioMedicine. 2019;45: 542-552.
Crossref Google Scholar
92

Elborn JS. Cystic fibrosis. Lancet. 2016;388(10059): 2519-2531.
Crossref Google Scholar
93

Naehrig S, Chao CM, Naehrlich L. Cystic fibrosis. Dtsch Arztebl Int. 2017;114(33–34): 564-574.
Crossref Google Scholar
94

Tsao FH, Meyer KC, Chen X, Rosenthal NS, Hu J. Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis. Am J Respir Cell Mol Biol. 1998;18(1): 120-128.
Crossref Google Scholar
95

Dalli J, Rosignoli G, Hayhoe RP, Edelman A, Perretti M. CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway. Am J Pathol. 2010;177(1): 176-186.
Crossref Google Scholar
96

Liu Y, Feng L, Wang H, et al. Identification of an anti-inflammation protein, annexin A1, in tendon derived stem cells (TDSCs) of cystic fibrosis mice: a comparative proteomic analysis. Proteomics Clin Appl. 2018;12(6): e1700162.
Crossref Google Scholar
97

Ma ZG, Yuan YP, Wu HM, Zhang X, Tang QZ. Cardiac fibrosis: new insights into the pathogenesis. Int J Biol Sci. 2018;14(12): 1645-1657.
Crossref Google Scholar
98

Park S, Nguyen NB, Pezhouman A, Ardehali R. Cardiac fibrosis: potential therapeutic targets. Transl Res. 2019;209: 121-137.
Crossref Google Scholar
99

Qin CX, Finlayson SB, Al-Sharea A, et al. Endogenous annexin-A1 regulates haematopoietic stem cell mobilisation and inflammatory response post myocardial infarction in mice in vivo. Sci Rep. 2017;7(1): 16615.
Crossref Google Scholar
100

Kosicka A, Cunliffe AD, Mackenzie R, et al. Attenuation of plasma annexin A1 in human obesity. FASEB J. 2013;27(1): 368-378.
Crossref Google Scholar
101

Li X, Zhao Y, Chen C, et al. Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity. Mol Cell Biol. 2020;40(8): e00564-19.
Crossref Google Scholar
102

Sakashita H, Yamada S, Kinoshita M, Kajikawa T, Iwayama T, Murakami S. Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion. Sci Rep. 2021;11(1): 4970.
Crossref Google Scholar
103

Mui L, Martin CM, Tschirhart BJ, Feng Q. Therapeutic potential of annexins in sepsis and COVID-19. Front Pharmacol. 2021;12: 735472.
Crossref Google Scholar
104

Gavins FN, Hickey MJ. Annexin A1 and the regulation of innate and adaptive immunity. Front Immunol. 2012;3: 354.
Crossref Google Scholar
105

Xu X, Gao W, Li L, et al. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway. J Neuroinflammation. 2021;18(1): 119.
Crossref Google Scholar
106

Wu L, Liu C, Chang DY, et al. The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through the AMPK/PPARα/CPT1b pathway. Diabetes. 2021;70(10): 2192-2203.
Crossref Google Scholar
107

Rüger M, Kipp E, Schubert N, et al. The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis. J Neuroinflammation. 2020;17(1): 325.
Crossref Google Scholar
108

Ferreira TPT, Guimarães FV, Sá YAPJ, et al. Annexin-A1-derived peptide Ac2-26 suppresses allergic airway inflammation and remodelling in mice. Cells. 2022;11(5): 759.
Crossref Google Scholar
109

Wang D, Cheng L, Li J, et al. Peptide DR8 analogs alleviate pulmonary fibrosis via suppressing TGF-β1 mediated epithelial-mesenchymal transition and ERK1/2 pathway in vivo and in vitro. Eur J Pharm Sci. 2021;167: 106009.
Crossref Google Scholar
110

Li Y, Zhang W, Zhao R, Zhang X. Advances in oral peptide drug nanoparticles for diabetes mellitus treatment. Bioact Mater. 2022;15: 392-408.
Crossref Google Scholar
111

Kamaly N, Fredman G, Subramanian M, et al. Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proc Natl Acad Sci U S A. 2013;110(16): 6506-6511.
Crossref Google Scholar
112

Leoni G, Neumann PA, Kamaly N, et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015;125(3): 1215-1227.
Crossref Google Scholar
113

Reischl S, Lee JH, Miltschitzky JRE, et al. Ac2-26-nanoparticles induce resolution of intestinal inflammation and anastomotic healing via inhibition of NF-κB signaling in a model of perioperative colitis. Inflamm Bowel Dis. 2021;27(9): 1379-1393.
Crossref Google Scholar
114

Li C, Zhao Y, Cheng J, et al. A proresolving peptide nanotherapy for site-specific treatment of inflammatory bowel disease by regulating proinflammatory microenvironment and gut microbiota. Adv Sci. 2019;6(18): 1900610.
Crossref Google Scholar
115

Ding Y, Flores J, Klebe D, et al. Annexin A1 attenuates neuroinflammation through FPR2/p38/COX-2 pathway after intracerebral hemorrhage in male mice. J Neurosci Res. 2020;98(1): 168-178.
Crossref Google Scholar
116

Corminboeuf O, Leroy X. FPR2/ALXR agonists and the resolution of inflammation. J Med Chem. 2015;58(2): 537-559.
Crossref Google Scholar
Genes & Diseases
Volume 9 Issue 6,
November 2022
Pages 1493-1505
DOI: 10.1016/j.gendis.2022.05.038
Cite this article:
Yan Z, Cheng X, Wang T, et al. Therapeutic potential for targeting Annexin A1 in fibrotic diseases. Genes & Diseases, 2022, 9(6): 1493-1505. https://doi.org/10.1016/j.gendis.2022.05.038

396

Views

3

Downloads

9

Crossref

7

Web of Science

7

Scopus

1

CSCD

Altmetrics
Received: 26 November 2021
Accepted: 30 May 2022
Published: 18 June 2022
© 2022, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return