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Rapid Communication | Open Access

SV40 large T antigen-induced immortalization reprograms mouse cardiomyocyte progenitors with mesenchymal stem cell characteristics and osteogenic potential

Yichun Yua,bJiamin Zhongb,cConnie ChenbYannian GoucGuozhi Zhaob,dPiao Zhaob,dYonghui Wangb,eWei Zengb,fAnnie WangbWilliam D. Wagstaff Jr.bRex C. HaydonbTong-Chuan Heb,gRussell R. Reidb,gMichael J. LeebHue H. Luub,( )Jiaming Fanb,c( )
Emergency Department, Beijing Hospital, and The National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100051, China
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
Ministry of Education Key Laboratory of Diagnostic Medicine, and the School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing 400016, China
Departments of Orthopaedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Department of Neurology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei 430050, China
Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA

Peer review under responsibility of Chongqing Medical University.

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References

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Li M, Chen Y, Bi Y, et al. Establishment and characterization of the reversibly immortalized mouse fetal heart progenitors. Int J Med Sci. 2013;10(8):1035–1046.

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Zhu JY, Abate M, Rice PW, et al. The ability of Simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J Virol. 1991;65(12):6872–6880.

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Yi L, Lu C, Hu W, et al. Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res. 2012;72(21):5635–5645.

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Mostafa S, Pakvasa M, Coalson E, et al. The wonders of BMP9: from mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine. Genes Dis. 2019;6(3):201–223.

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Pakvasa M, Haravu P, Boachie-Mensah M, et al. Notch signaling: its essential roles in bone and craniofacial development. Genes Dis. 2021;8(1):8–24.

Genes & Diseases
Pages 1161-1164
Cite this article:
Yu Y, Zhong J, Chen C, et al. SV40 large T antigen-induced immortalization reprograms mouse cardiomyocyte progenitors with mesenchymal stem cell characteristics and osteogenic potential. Genes & Diseases, 2023, 10(4): 1161-1164. https://doi.org/10.1016/j.gendis.2022.10.008

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Received: 19 July 2022
Published: 21 October 2022
© 2022 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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