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Rapid Communication | Open Access

NRF2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING pathway

Sun Xiaodana,Zhao PeiyanaLi HuibLiu YanbCheng Yingc ( )
Postdoctoral Research Workstation, Jilin Cancer Hospital, Changchun, Jilin 130012, China
Translational Cancer Research, Jilin Cancer Hospital, Changchun, Jilin 130012, China
Department of Medical Thoracic Oncology, Jilin Cancer Hospital, Changchun, Jilin 130012, China

Peer review under responsibility of Chongqing Medical University.

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References

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Skoulidis F, Heymach JV. Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. Nat Rev Cancer. 2019;19(9):495-509.

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Cai MC, Chen M, Ma P, et al. Clinicopathological, microenvironmental and genetic determinants of molecular subtypes in KEAP1/NRF2-mutant lung cancer. Int J Cancer. 2019;144(4):788-801.

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Do HTT, Lee CH, Cho J. Chemokines and their receptors: multifaceted roles in cancer progression and potential value as cancer prognostic markers. Cancers. 2020;12(2):287.

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Sen T, Rodriguez BL, Chen L, et al. Targeting DNA damage response promotes antitumor immunity through STING-mediated T-cell activation in small cell lung cancer. Cancer Discov. 2019;9(5):646-661.

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Haag SM, Gulen MF, Reymond L, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018;559(7713):269-273.

Genes & Diseases
Pages 1727-1730
Cite this article:
Xiaodan S, Peiyan Z, Hui L, et al. NRF2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING pathway. Genes & Diseases, 2023, 10(5): 1727-1730. https://doi.org/10.1016/j.gendis.2022.10.009

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Received: 24 March 2022
Published: 25 October 2022
© 2022 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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