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Review Article | Open Access

Lysine succinylation, the metabolic bridge between cancer and immunity

Rui Shena,1, Hongyun Ruanb,1, Shuye Linb,1, Bin Liub, Hang Songa,c (), Lu Lia,c(), Teng Mab()
School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China
Cancer Research Centre, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Abstract

Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal regulation of lysine succinylation occurs in different cancers, and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies. Therefore, this review focused on the target protein lysine succinylation and its functions in cancer and immunity, in order to provide a reference for finding more potential clinical cancer targets in the future.

Keywords

ImmunityMitochondriaSIRT5Succinyl-CoASuccinylation

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Genes & Diseases
Volume 10 Issue 6,
November 2023
Pages 2470-2478
DOI: 10.1016/j.gendis.2022.10.028
Cite this article:
Shen R, Ruan H, Lin S, et al. Lysine succinylation, the metabolic bridge between cancer and immunity. Genes & Diseases, 2023, 10(6): 2470-2478. https://doi.org/10.1016/j.gendis.2022.10.028
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