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Review Article | Open Access

Epigenetic regulation of mesenchymal stem cell aging through histone modifications

Yanping Sun,1, Haoyu Zhang,1, Tao Qiu,, Li Liao, Xiaoxia Su( )
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatrics & Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China

1 These authors contributed equally to this manuscript.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

Stem cell senescence and exhaustion, a hallmark of aging, lead to declines in tissue repair and regeneration in aged individuals. Emerging evidence has revealed that epigenetic regulation plays critical roles in the self-renew, lineage-commitment, survival, and function of stem cells. Moreover, epigenetic alterations are considered important drivers of stem cell dysfunction during aging. In this review, we focused on current knowledge of the histone modifications in the aging of mesenchymal stem cells (MSCs). The aberrant epigenetic modifications on histones, including methylation and acetylation, have been found in aging MSCs. By disturbing the expression of specific genes, these epigenetic modifications affect the self-renew, survival, and differentiation of MSCs. A set of epigenetic enzymes that write or erase these modifications are critical in regulating the aging of MSCs. Furthermore, we discussed the rejuvenation strategies based on epigenetics to prevent stem cell aging and/or rejuvenate senescent MSCs.

Keywords

Mesenchymal stem cellAgingEpigeneticHistone acetylationHistone methylation

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Genes & Diseases
Volume 10 Issue 6,
November 2023
Pages 2443-2456
DOI: 10.1016/j.gendis.2022.10.030
Cite this article:
Sun Y, Zhang H, Qiu T, et al. Epigenetic regulation of mesenchymal stem cell aging through histone modifications. Genes & Diseases, 2023, 10(6): 2443-2456. https://doi.org/10.1016/j.gendis.2022.10.030

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Received: 11 May 2022
Revised: 18 August 2022
Accepted: 23 October 2022
Published: 05 December 2022
© 2022 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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