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Rapid Communication | Open Access

Clinical utilization of olaparib, a PARP inhibitor, in BRCA1-mutant metastatic acral melanoma

Ruixin Jianga,c,1Xianbin Liangb,1Ye Taoa,cRonghui XiadMing LeicBin JiangaRobert L. Judson-Torrese,fYanjie Zhanga,c()Weizhen Zhangb()Hanlin Zenga,c()
Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
Department of Oncology, The Third People's Hospital of Zhengzhou; Zhengzhou, Henan 450000, China
Shanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
Department of Oral & Maxillofacial - Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
Department of Dermatology, University of Utah, Salt Lake City, UT 84132, USA
Huntsman Cancer Institute, Salt Lake City, UT 84112, USA

1 Co-first authors.

Peer review under responsibility of Chongqing Medical University.

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References

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Hayward NK, Wilmott JS, Waddell N, et al. Whole-genome landscapes of major melanoma subtypes. Nature. 2017;545(7653):175-180.

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Yeh I, Jorgenson E, Shen L, et al. Targeted genomic profiling of acral melanoma. J Natl Cancer Inst. 2019;111(10):1068-1077.

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Byeon S, Cho HJ, Jang KT, et al. Molecular profiling of Asian patients with advanced melanoma receiving check-point inhibitor treatment. ESMO Open. 2021;6(1):100002.

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U.S. Food & Drug Administration. Drugs@FDA: FDA-approved drugs. Accessed December 1, 2021. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm.
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Shain AH, Bastian BC. From melanocytes to melanomas. Nat Rev Cancer. 2016;16(6):345-358.

Genes & Diseases
Pages 1755-1758
Cite this article:
Jiang R, Liang X, Tao Y, et al. Clinical utilization of olaparib, a PARP inhibitor, in BRCA1-mutant metastatic acral melanoma. Genes & Diseases, 2023, 10(5): 1755-1758. https://doi.org/10.1016/j.gendis.2022.11.014
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