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Review Article | Open Access

The emerging role of snoRNAs in human disease

Xinhai Zhanga,1, Chenglong Wanga,1, Shujun Xiab,1, Fei Xiaoa,, Jianping Penga, Yuxuan Gaoc, Fengbin Yud, Chuandong Wanga( ), Xiaodong Chena( )
Department of Orthopedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200092, China
Ultrasound Department, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China
Department of Orthopaedic Surgery, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
Department of Orthopaedics, The 72nd Group Army Hospital of PLA, Huzhou, Zhejiang 313000, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The aberrant expression or depletion of snoRNAs is related to various diseases. In previous research, most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs, whose typical functions were thought of as regulation of 2’-O-ribose methylation and pseudouridylation of ribosome RNAs, respectively. However, in the past two decades, studies have revealed an increasing number of snoRNAs without specific targets or determined cell functions. These findings indicated that some potential roles of snoRNAs are still unknown. Numerous studies have indicated the correlation of snoRNAs with human diseases. SnoRNAs play various roles in abundant biological processes, and they have great potential in controlling human diseases. This new and rising field could benefit from investigations of the disease pathogenesis, biomarker identification, and the determination of novel therapeutic targets. This review summarized the reports on snoRNAs and the regulation of different diseases in recent years.

Keywords

InflammationCancerMetabolismGenetic diseaseSmall nucleolar RNAs

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Genes & Diseases
Volume 10 Issue 5,
September 2023
Pages 2064-2081
DOI: 10.1016/j.gendis.2022.11.018
Cite this article:
Zhang X, Wang C, Xia S, et al. The emerging role of snoRNAs in human disease. Genes & Diseases, 2023, 10(5): 2064-2081. https://doi.org/10.1016/j.gendis.2022.11.018

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Received: 28 May 2022
Revised: 01 November 2022
Accepted: 16 November 2022
Published: 26 December 2022
© 2022 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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