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Rapid Communication | Open Access

LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin

Wen Penga,d,1Jiayi Zhanga,c,1Shenghao WangdFeng Wanga,dKun Wanga,dRui GengdXiangfei DingdJingping ZhangdBiao LidXiaoxue Kea,d( )Muhan Lüb( )Hongjuan Cuia,d,e,( )
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
Chongqing Institute for Food and Drug Control, Chongqing 401121, China
Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China
Jinfeng Laboratory, Chongqing 401329, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Qin J, Ning H, Zhou Y, et al. LncRNA MIR31HG overexpression serves as poor prognostic biomarker and promotes cell proliferation in lung adenocarcinoma. Biomed Pharmacother. 2018;99:363-368.

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Eide PW, Eilertsen IA, Sveen A, et al. Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties. Int J Cancer. 2019;144(11):2843-2853.

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Valenta T, Hausmann G, Basler K. The many faces and functions of β-catenin. EMBO J. 2012;31(12):2714-2736.

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Zheng S, Zhang X, Wang X, et al. MIR31HG promotes cell proliferation and invasion by activating the Wnt/β-catenin signaling pathway in non-small cell lung cancer. Oncol Lett. 2019;17(1):221-229.

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Levkowitz G, Waterman H, Ettenberg SA, et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell. 1999;4(6):1029-1040.

Genes & Diseases
Pages 712-715
Cite this article:
Peng W, Zhang J, Wang S, et al. LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin. Genes & Diseases, 2023, 10(3): 712-715. https://doi.org/10.1016/j.gendis.2022.12.022

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Received: 16 May 2022
Published: 26 March 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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