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Rapid Communication | Open Access

Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells

Yuanfa Yaoa,b,c,,1, Hanbing Lic,1, Xinyi Wangb,1, Yuanhai Sunc, Xuqin Zhaoc, Weiwei Zhac, Jiaqiang Zhoud, Derek Toomree, Junfen Fua, Yingke Xua,b,e,f( )
Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children’s Health, Hangzhou, Zhejiang 310051, China
Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, Zhejiang 310027, China
Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China
Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang 310053, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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Genes & Diseases
Volume 10 Issue 5,
September 2023
Pages 1787-1790
DOI: 10.1016/j.gendis.2023.01.007
Cite this article:
Yao Y, Li H, Wang X, et al. Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells. Genes & Diseases, 2023, 10(5): 1787-1790. https://doi.org/10.1016/j.gendis.2023.01.007

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Received: 22 July 2022
Published: 03 February 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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