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Review Article | Open Access

Fantastic voyage: The journey of NLRP3 inflammasome activation

Xiangyong Quea,1, Sihao Zhenga,1, Qibin Songa, Huadong Peib( ), Pingfeng Zhanga( )
Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China
Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

NLRP3 inflammasome, an intracellular multiprotein complex, can be activated by a range of pathogenic microbes or endogenous hazardous chemicals. Its activation results in the release of cytokines such as IL-1β and IL-18, as well as Gasdermin D which eventually causes pyroptosis. The activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and mechanisms. Its excessive activation can lead to a persistent inflammatory response, which is linked to the onset and progression of severe illnesses. Recent studies have revealed that the subcellular localization of NLRP3 changes significantly during the activation process. In this review, we review the current understanding of the molecular mechanism of NLRP3 inflammasome activation, focusing on the subcellular localization of NLRP3 and the associated regulatory mechanisms. We aim to provide a comprehensive understanding of the dynamic transportation, activation, and degradation processes of NLRP3.

Keywords

Inflammasome activationInnate immunityNLRP3NLRP3 inflammasomeSubcellular localization

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Genes & Diseases
Volume 11 Issue 2,
March 2024
Pages 819-829
DOI: 10.1016/j.gendis.2023.01.009
Cite this article:
Que X, Zheng S, Song Q, et al. Fantastic voyage: The journey of NLRP3 inflammasome activation. Genes & Diseases, 2024, 11(2): 819-829. https://doi.org/10.1016/j.gendis.2023.01.009

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Received: 07 December 2022
Accepted: 07 January 2023
Published: 23 March 2023
© Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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