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Review Article | Open Access

Decoding m6A mRNA methylation by reader proteins in liver diseases

Lijiao Suna,b,c,1, Xin Chena,b,c,1, Sai Zhua,d,1, Jianan Wanga,b,, Shaoxi Diaoa,b,c, Jinyu Liua,b,c, Jinjin Xua,b,c, Xiaofeng Lia,b, Yingyin Suna,e, Cheng Huanga,b,c, Xiaoming Menga,b, Xiongwen Lva,b,c( ), Jun Lia,b,c( )
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China
The Key Laboratory of Anti-inflammatory and Immune Medicines, Anhui Medical University, Ministry of Education, Hefei, Anhui 230032, China
Institute for Liver Diseases of Anhui Medical University, ILD-AMU, Anhui Medical University, Hefei, Anhui 230032, China
Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

N6-methyladenosine (m6A) is a dynamic and reversible epigenetic regulation. As the most prevalent internal post-transcriptional modification in eukaryotic RNA, it participates in the regulation of gene expression through various mechanisms, such as mRNA splicing, nuclear export, localization, translation efficiency, mRNA stability, and structural transformation. The involvement of m6A in the regulation of gene expression depends on the specific recognition of m6A-modified RNA by reader proteins. In the pathogenesis and treatment of liver disease, studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m6A modification, in which abnormal expression of reader proteins determines the fate of these gene transcripts. In this review, we introduce m6A readers, summarize the recognition and regulatory mechanisms of m6A readers on mRNA, and focus on the biological functions and mechanisms of m6A readers in liver cancer, viral hepatitis, non-alcoholic fatty liver disease (NAFLD), hepatic fibrosis (HF), acute liver injury (ALI), and other liver diseases. This information is expected to be of high value to researchers deciphering the links between m6A readers and human liver diseases.

Keywords

Liver diseasesm6A modificationIGF2BPsm6A readermRNA metabolismYTH domain protein

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Genes & Diseases
Volume 11 Issue 2,
March 2024
Pages 711-726
DOI: 10.1016/j.gendis.2023.02.054
Cite this article:
Sun L, Chen X, Zhu S, et al. Decoding m6A mRNA methylation by reader proteins in liver diseases. Genes & Diseases, 2024, 11(2): 711-726. https://doi.org/10.1016/j.gendis.2023.02.054

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Received: 03 October 2022
Accepted: 22 February 2023
Published: 13 April 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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