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Full Length Article | Open Access

PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

Fengsheng Daia,b,1, Yixiao Yuana,1, Jiaqi Haoc,d,1, Xing Chenge, Xiangyi Zhoua, Li Zhoub, Rui Tianb, Yi Zhaob, Tingxiu Xianga,b,( )
Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Abstract

Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis remains unclear. The TCGA, CGGA, GEPIA, cBioPortal, and GTEx databases were analyzed for expression, prognostic value, and genetic modifications of PDCD2 in cancer patients. Functional enrichment analysis, CCK8, colony formation assay, transwell assay, and xenograft tumor model were undertaken to study the PDCD2’s biological function in glioma (GBMLGG). The PDCD2 gene was associated with solid cancer progression. In the functional enrichment analysis results, PDCD2 was shown to participate in several important GBMLGG biological processes. GBMLGG cells may be inhibited in their proliferation, migration, invasion, and xenograft tumor growth by knocking down PDCD2. Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

Keywords

GliomaBiomarkerProgressionProgrammed cell death 2Solid cancer

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Genes & Diseases
Volume 11 Issue 5,
September 2024
Article number: 101106
DOI: 10.1016/j.gendis.2023.101106
Cite this article:
Dai F, Yuan Y, Hao J, et al. PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype. Genes & Diseases, 2024, 11(5): 101106. https://doi.org/10.1016/j.gendis.2023.101106

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Received: 28 March 2023
Accepted: 04 August 2023
Published: 21 September 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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