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Rapid Communication | Open Access

Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1α

Xiangyu Suna,b,,1Qiang Zhangb,1Mozhi WangaLitong YaoaXiang LicHongyi CaodYingying Xua( )
Department of Breast Surgery, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110000, China
Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110000, China
Department of Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning 110000, China
Department of Pathology, The First Hospital of China Medical University and College of Basic Medical Sciences, Shenyang, Liaoning 110000, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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Pan C, Li B, Simon MC. Moonlighting functions of metabolic enzymes and metabolites in cancer. Mol Cell. 2021;81(18):3760–3774.

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Hunt MC, Alexson SEH. The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism. Prog Lipid Res. 2002;41(2):99–130.

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Sica V, Bravo-San Pedro JM, Stoll G, Kroemer G. Oxidative phosphorylation as a potential therapeutic target for cancer therapy. Int J Cancer. 2020;146(1):10–17.

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Haemmerle G, Moustafa T, Woelkart G, et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med. 2011;17(9):1076–1085.

Genes & Diseases
Article number: 101149
Cite this article:
Sun X, Zhang Q, Wang M, et al. Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1α. Genes & Diseases, 2024, 11(5): 101149. https://doi.org/10.1016/j.gendis.2023.101149

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Received: 04 January 2023
Published: 20 October 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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