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Rapid Communication | Open Access

Syrosingopine, an anti-hypertensive drug and lactate transporter (MCT1/4) inhibitor, activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model

Meichun Guoa, Yannian Goua, Xiangyu Donga, Jiamin Zhonga,b, Aohua Lia, Ailing Haoa, Tong-Chuan Heb, Jiaming Fana,( )
Ministry of Education Key Laboratory of Diagnostic Medicine, and the School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing 400016, China
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA

Peer review under responsibility of Chongqing Medical University.

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References

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Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspect Med. 2019;65:37-55.
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Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27-42.
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Genes & Diseases
Volume 11 Issue 4,
July 2024
Article number: 101169
DOI: 10.1016/j.gendis.2023.101169
Cite this article:
Guo M, Gou Y, Dong X, et al. Syrosingopine, an anti-hypertensive drug and lactate transporter (MCT1/4) inhibitor, activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model. Genes & Diseases, 2024, 11(4): 101169. https://doi.org/10.1016/j.gendis.2023.101169

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Received: 26 June 2023
Published: 18 November 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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