The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy

Wenze Cao; Huan Liu; Ye Xu; Sangyu Hu; Yujie Yang; Li Li; Luying Peng

doi:10.1016/j.gendis.2023.101183

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Rapid Communication | Open Access

The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy

Wenze Cao^{^a^,^b^,^c^,¹}, Huan Liu^{^a^,^b^,^c^,¹}, Ye Xu^{^a^,^b^,^c}, Sangyu Hu^{^a^,^b^,^c}, Yujie Yang^{^a^,^b^,^c^,^d}, Li Li^{^a^,^b^,^c^,^d^,^e}(), Luying Peng^{^a^,^b^,^c^,^d^,^e}()

State Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Institute of Medical Genetics, Tongji University, Shanghai 200092, China

Heart Health Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Department of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China

Research Units of Origin and Regulation of Heart Rhythm, Chinese Academy of Medical Sciences, Beijing 100730, China

¹ These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

Inazumi H, Kuwahara K. NRSF/REST-mediated epigenomic regulation in the heart: transcriptional control of natriuretic peptides and beyond. Biology. 2022;11(8):1197.

Crossref Google Scholar

Inazumi H, Kuwahara K, Nakagawa Y, et al. NRSF- GNAO1 pathway contributes to the regulation of cardiac Ca²⁺ homeostasis. Circ Res. 2022;130(2):234–248.

Crossref Google Scholar

Barrachina M, Moreno J, Juvés S, Moreno D, Olivé M, Ferrer I. Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy. Am J Pathol. 2007;171(4):1312–1323.

Crossref Google Scholar

Bi HL, Zhang XL, Zhang YL, et al. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Sci Adv. 2020;6(16):eaax4826.

Crossref Google Scholar

Li H, Liu Z, Wu Y, et al. The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson’s disease. Biochim Biophys Acta, Mol Basis Dis. 2020;1866(1):165590.

Crossref Google Scholar

Genes & Diseases

Volume 11 Issue 6,
November 2024

Article number: 101183

DOI: 10.1016/j.gendis.2023.101183

Cite this article:

Cao W, Liu H, Xu Y, et al. The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy. Genes & Diseases, 2024, 11(6): 101183. https://doi.org/10.1016/j.gendis.2023.101183