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Review Article | Open Access

The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells

Jin Zhanga, Lingling Tonga, Yuchen Liub, Xiang Lib, Jiayi Wangb, Ruoxin Linb, Ziyu Zhoub, Yunbing Chenb, Yanxi Chenb, Yirong Liuc, Di Chena,d( )
Center for Reproductive Medicine of the Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China
National Key Laboratory of Biobased Transportation Fuel Technology, Haining, Zhejiang 314400, China

Peer review under responsibility of Chongqing Medical University.

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Abstract

As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m6A modification is regulated by m6A writers, erasers, and readers. Emerging evidence suggests that m6A modification plays essential roles in modulating the cell-fate transition of embryonic stem cells. Mechanistic investigation of embryonic stem cell maintenance and differentiation is critical for understanding early embryonic development, which is also the premise for the application of embryonic stem cells in regenerative medicine. This review highlights the current knowledge of m6A modification and its essential regulatory contribution to the cell fate transition of mouse and human embryonic stem cells.

Keywords

Cell-fate transitionEmbryonic stem cellEpigenetic modificationm6A modificationPost-transcriptional regulation

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Genes & Diseases
Volume 11 Issue 5,
September 2024
Article number: 101199
DOI: 10.1016/j.gendis.2023.101199
Cite this article:
Zhang J, Tong L, Liu Y, et al. The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells. Genes & Diseases, 2024, 11(5): 101199. https://doi.org/10.1016/j.gendis.2023.101199

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Received: 24 August 2023
Revised: 28 October 2023
Accepted: 11 November 2023
Published: 19 December 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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