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Rapid Communication | Open Access

MMP-9 deficiency accelerates the progress of periodontitis

Chun-Yan Wana,bYixin Yinb,cXiaoyan Lib,dMeng Meng LiubGraham GoldmanbLi-An Wub,eFeng Wangb,fDao-Shu Luob,fZhuo Chenb,gWen-An Xub,hStephen ChenbMary MacDougalliMerry L. LindseyjZhi ChenkShuo Chenb( )
Department of Endodontics, The Affiliated Hospital of Qingdao University, School of Stomatology, Qingdao University, Qingdao, Shandong 266003, China
Department of Developmental Dentistry, School of Dentistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Oral Implantology Center, Jinan Stomatological Hospital, Jinan, Shandong 250001, China
Department of Endodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong University, Jinan, Shandong 250012, China
Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China
Laboratory of Clinical Applied Anatomy, Department of Human Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, China
Key Laboratory for Oral Biomedical Research of Zhejiang Province, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang 310027, China
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
UBC Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
School of Graduate Studies and Research, Meharry Medical College and Research Biologist, Research Service Nashville VA Medical Center, Nashville, TN 37208, USA
State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei- MOST), Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China

Peer review under responsibility of Chongqing Medical University.

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References

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Tan J, Dai A, Pan L, et al. Inflamm-aging-related cytokines of IL-17 and IFN-γ accelerate osteoclastogenesis and periodontal destruction. J Immunol Res. 2021;2021:9919024.

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Michaud DS, Fu Z, Shi J, Chung M. Periodontal disease, tooth loss, and cancer risk. Epidemiol Rev. 2017;39(1):49-58.

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Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix metalloproteinase-3 but not matrix metalloproteinase-9, implicated in the manifestation of chronic periodontitis. Rep Biochem Mol Biol. 2023;11(4):656-662.

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Sharony R, Borochowitz Z, Cohen L, et al. Prenatal course of metaphyseal anadysplasia associated with homozygous mutation in MMP9 identified by exome sequencing. Clin Genet. 2017;92(6):645-648.

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Wan C, Yuan G, Yang J, et al. MMP9 deficiency increased the size of experimentally induced apical periodontitis. J Endod. 2014;40(5):658-664.

Genes & Diseases
Article number: 101231
Cite this article:
Wan C-Y, Yin Y, Li X, et al. MMP-9 deficiency accelerates the progress of periodontitis. Genes & Diseases, 2024, 11(5): 101231. https://doi.org/10.1016/j.gendis.2024.101231

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Received: 26 July 2022
Published: 28 January 2024
© 2024 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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