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Review Article | Open Access

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Jiankun Fana,1, Zhigang Lia,1, Li Peib( ), Yu Houa( )
Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China
Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

Abstract

Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events, including RNA alternative splicing, RNA localization, RNA degradation, and storage. Notably, post-transcriptional regulation plays a pivotal role in preserving hematopoietic homeostasis. The DEAD-Box RNA helicase genes emerge as crucial post-transcriptional regulatory factors, intricately involved in sustaining normal hematopoiesis through diverse mechanisms such as RNA alternative splicing, RNA modification, and ribosome assembly. This review consolidates the existing knowledge on the role of DEAD-box RNA helicases in regulating normal hematopoiesis and underscores the pathogenicity of mutant DEAD-Box RNA helicases in malignant hematopoiesis. Emphasis is placed on elucidating both the positive and negative contributions of DEAD-box RNA helicases within the hematopoietic system.

Keywords

DEAD-box RNA helicaseHemopoietic systemPost-transcriptional regulationRibosomes assemblyRNA alternative splicing

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Genes & Diseases
Volume 11 Issue 5,
September 2024
Article number: 101252
DOI: 10.1016/j.gendis.2024.101252
Cite this article:
Fan J, Li Z, Pei L, et al. Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies. Genes & Diseases, 2024, 11(5): 101252. https://doi.org/10.1016/j.gendis.2024.101252

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Received: 31 May 2023
Revised: 01 February 2024
Accepted: 11 February 2024
Published: 28 February 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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