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Rapid Communication | Open Access

A novel metabolite-interacting protein (MIP)-based molecular subtyping construction and validation of IGFBP3 as a MIP-related oncogene in colorectal cancer

Simeng Baoa,1Yongmin Lib,1Yu LiangbJianxun DaicHuolin HuangcBin Mab,d()
Central Laboratory, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China
Department of Colorectal Surgery, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China
School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, Liaoning 116024, China
The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, Shenyang, Liaoning 110042, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Andrei P, Battuello P, Grasso G, Rovera E, Tesio N, Bardelli A. Integrated approaches for precision oncology in colorectal cancer: the more you know, the better. Semin Cancer Biol. 2022;84:199–213.

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Liu Z, Xu H, Weng S, Ren Y, Han X. Stemness refines the classification of colorectal cancer with stratified prognosis, multi-omics landscape, potential mechanisms, and treatment options. Front Immunol. 2022;13:828330.

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Dong S, Liang S, Cheng Z, et al. ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. J Exp Clin Cancer Res. 2022;41(1):15.

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Chen D, Zhang Y, Wang W, et al. Identification and characterization of robust hepatocellular carcinoma prognostic subtypes based on an integrative metabolite-protein interaction network. Adv Sci. 2021;8(17):e2100311.

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Piazza I, Kochanowski K, Cappelletti V, et al. A map of protein-metabolite interactions reveals principles of chemical communication. Cell. 2018;172(1–2):358–372.e23.

Genes & Diseases
Article number: 101272
Cite this article:
Bao S, Li Y, Liang Y, et al. A novel metabolite-interacting protein (MIP)-based molecular subtyping construction and validation of IGFBP3 as a MIP-related oncogene in colorectal cancer. Genes & Diseases, 2025, 12(2): 101272. https://doi.org/10.1016/j.gendis.2024.101272
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