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Rapid Communication | Open Access

The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma

Jianhong Zhang1Chengyang Song1Xiuqin FengQian YuXueying Yang()
Department of Thoracic and Cardiac Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work and shared the first authorship.

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References

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Jew B, Alvarez M, Rahmani E, et al. Accurate estimation of cell composition in bulk expression through robust integration of single-cell information. Nat Commun. 2020;11(1):1971.

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van de Donk NWCJ, Usmani SZ, Yong K. CAR T-cell therapy for multiple myeloma: state of the art and prospects. Lancet Haematol. 2021;8(6):e446-e461.

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Kurebayashi Y, Emoto K, Hayashi Y, et al. Comprehensive immune profiling of lung adenocarcinomas reveals four immunosubtypes with plasma cell subtype a negative indicator. Cancer Immunol Res. 2016;4(3):234-247.

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Lohr M, Edlund K, Botling J, et al. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Lett. 2013;333(2):222-228.

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Patil NS, Nabet BY, Müller S, et al. Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell. 2022;40(3):289-300.e4.

Genes & Diseases
Article number: 101274
Cite this article:
Zhang J, Song C, Feng X, et al. The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma. Genes & Diseases, 2025, 12(2): 101274. https://doi.org/10.1016/j.gendis.2024.101274
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