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Rapid Communication | Open Access

CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition

Miao Wanga,1Lin Chenb,1Yu Wangc,1Tian FanbChunyu ZhuaZhixian LibLei MoubHong Yangd( )Airong Qiana ( )Yu Lib( )
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China
Xi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China
Department of Oncology, Air Force Medical Center, PLA, Beijing 100142, China
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi 710032, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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References

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Landras A, de Moura CR, Jouenne F, Lebbe C, Menashi S, Mourah S. CD147 is a promising target of tumor progression and a prognostic biomarker. Cancers. 2019;11(11):1803.

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Bian H, Zheng JS, Nan G, et al. Randomized trial of [131I] metuximab in treatment of hepatocellular carcinoma after percutaneous radiofrequency ablation. J Natl Cancer Inst. 2014;106(9):dju239.

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Wu B, Liu ZY, Cui J, et al. F-box protein FBXO22 mediates polyubiquitination and degradation of CD147 to reverse cisplatin resistance of tumor cells. Int J Mol Sci. 2017;18(1):212.

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Bu X, Qu X, Guo K, et al. CD147 confers temozolomide resistance of glioma cells via the regulation of β-TrCP/Nrf2 pathway. Int J Biol Sci. 2021;17(12):3013–3023.

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Chen Y, Li Y, Xue J, et al. Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J. 2016;35(6):668–684.

Genes & Diseases
Article number: 101277
Cite this article:
Wang M, Chen L, Wang Y, et al. CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition. Genes & Diseases, 2024, 11(5): 101277. https://doi.org/10.1016/j.gendis.2024.101277

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Received: 31 July 2023
Published: 24 March 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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