Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r)P853T/+ in CSF1R-microglial encephalopathy

Xiaohong Wang; Yanli Wang; Tianlin Jiang; Jiwei Jiang; Linlin Wang; Shiyi Yang; Mengfan Sun; Yuan Zhang; Ziyan Jia; Wenyi Li; Qiwei Ren; Cuicui Zhang; Jianjian Liu; Yinwei Zhu; Min Zhao; Shirui Jiang; Huiying Zhang; Jinglong Chen; Jun Xu

doi:10.1016/j.gendis.2024.101289

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Rapid Communication | Open Access

Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r)^P853T/+ in CSF1R-microglial encephalopathy

Xiaohong Wang^{^a^,¹}, Yanli Wang^{^b^,^c^,¹}, Tianlin Jiang^{^b^,¹}, Jiwei Jiang^{^b}, Linlin Wang^{^b}, Shiyi Yang^{^b}, Mengfan Sun^{^b}, Yuan Zhang^{^b}, Ziyan Jia^{^b}, Wenyi Li^{^b}, Qiwei Ren^{^b}, Cuicui Zhang^{^d}, Jianjian Liu^{^e}, Yinwei Zhu^{^f}, Min Zhao^{^b}, Shirui Jiang^{^b}, Huiying Zhang^{^b}, Jinglong Chen^{^g}, Jun Xu^{^b}()

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, China

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

School of Public Health, Shandong Second Medical University, Weifang, Shandong 261000, China

Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

Department of Neurology, Fuxing Hospital, Capital Medical University, Beijing 100045, China

Department of Neurology, Changshu Hospital Affiliated to Soochow University/Changshu First People’s Hospital, Changshu, Jiangsu 215500, China

Department of Geriatric Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China

¹ These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Li X, Hu B, Guan X, et al. Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). J Neuroinflammation. 2023;20(1):134.

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Genes & Diseases

Volume 12 Issue 2,
March 2025

Article number: 101289

DOI: 10.1016/j.gendis.2024.101289

Cite this article:

Wang X, Wang Y, Jiang T, et al. Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r)^P853T/+ in CSF1R-microglial encephalopathy. Genes & Diseases, 2025, 12(2): 101289. https://doi.org/10.1016/j.gendis.2024.101289