Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma

Yueying Gao; Jinyang Yu; Zhi Li; Kefan Liu; Jiwei Pan; Ya Zhang; Yanlin Ma; Jiwei Zhang; Zhigang Liu; Yongsheng Li

doi:10.1016/j.gendis.2024.101302

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Rapid Communication | Open Access

Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma

Yueying Gao^{^a^,^b^,¹}, Jinyang Yu^{^a^,¹}, Zhi Li^{^c^,¹}, Kefan Liu^{^b}, Jiwei Pan^{^a}, Ya Zhang^{^a}, Yanlin Ma^{^a}(), Jiwei Zhang^{^c}(), Zhigang Liu^{^d}(), Yongsheng Li^{^a^,^b}()

Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Department of Reproductive Medicine, Hainan Provincial Clinical Research Center for Thalassemia, Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, College of Biomedical Information and Engineering, Hainan Medical University, Haikou, Hainan 571101, China

School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, Heilongjiang 150081, China

The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Guangzhou, Guangdong 510000, China

Peer review under responsibility of Chongqing Medical University.

¹ These authors contributed equally to this work.

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Genes & Diseases

Volume 12 Issue 2,
March 2025

Article number: 101302

DOI: 10.1016/j.gendis.2024.101302

Cite this article:

Gao Y, Yu J, Li Z, et al. Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma. Genes & Diseases, 2025, 12(2): 101302. https://doi.org/10.1016/j.gendis.2024.101302