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Rapid Communication | Open Access

ZIP4 inhibits Ephrin-B1 ubiquitination, activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis

Haijun Guoa,1Renyi Sub,1Xinfeng LucHui ZhangcXuyong Weia( )Xiao Xub,d( )
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China
Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
The Fourth School of Clinical Medicine, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310053, China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

1

Andrews GK. Regulation and function of Zip4, the acrodermatitis enteropathica gene. Biochem Soc Trans. 2008;36(Pt 6):1242–1246.

2

Liu M, Zhang Y, Yang J, et al. ZIP4 increases expression of transcription factor ZEB1 to promote integrin α3β1 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic cancer cells. Gastroenterology. 2020;158(3):679–692.e1.

3

Liu M, Yang J, Zhang Y, et al. ZIP4 promotes pancreatic cancer progression by repressing ZO-1 and claudin-1 through a ZEB1-dependent transcriptional mechanism. Clin Cancer Res. 2018;24(13):3186–3196.

4

Zeng Q, Liu YM, Liu J, et al. Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells. Cell Death Dis. 2019;10(8):588.

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Xu X, Guo HJ, Xie HY, et al. ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation. Int J Biol Sci. 2014;10(3):245–256.

Genes & Diseases
Article number: 101312
Cite this article:
Guo H, Su R, Lu X, et al. ZIP4 inhibits Ephrin-B1 ubiquitination, activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis. Genes & Diseases, 2024, 11(6): 101312. https://doi.org/10.1016/j.gendis.2024.101312

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Received: 26 September 2023
Published: 24 April 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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