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Rapid Communication | Open Access

Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma

Jie Caia,1Weizhong Ruanb,1Zida Wangc,1Gongzhe LiudBei YangaHao WangaDeping Zhaoa()Chang Chena()Xiaogang Zhaoa()
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital (Fujian Branch of Fudan University Shanghai Cancer Center), Fuzhou, Fujian 350014, China
Department of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
Department of Cardiothoracic Surgery, People’s Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 271199, China

1 These authors have contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17-48.

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Chaft JE, Rimner A, Weder W, Azzoli CG, Kris MG, Cascone T. Evolution of systemic therapy for stages Ⅰ-Ⅲ non-metastatic non-small-cell lung cancer. Nat Rev Clin Oncol. 2021;18(9):547-557.

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Xie M, Yu J, Ge S, Huang J, Fan X. SUMOylation homeostasis in tumorigenesis. Cancer Lett. 2020;469:301-309.

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Hu FF, Liu CJ, Liu LL, Zhang Q, Guo AY. Expression profile of immune checkpoint genes and their roles in predicting immunotherapy response. Briefings Bioinf. 2021;22(3):bbaa176.

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Chan TA, Yarchoan M, Jaffee E, et al. Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic. Ann Oncol. 2019;30(1):44-56.

Genes & Diseases
Article number: 101338
Cite this article:
Cai J, Ruan W, Wang Z, et al. Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma. Genes & Diseases, 2025, 12(2): 101338. https://doi.org/10.1016/j.gendis.2024.101338
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