Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy

Xun Qiu; Hanzhi Xu; Yawen Tan; Jinying Li; Zhoucheng Wang; Zhengxing Lian; Xuyong Wei; Luyang Yu; Kai Wang; Xiao Xu

doi:10.1016/j.gendis.2024.101343

| Sign up

PDF (861.2 KB)

Cite

EndNote(RIS) BibTeX

Collect

Submit Manuscript

Show Outline

Outline

References

Show full outline

Hide outline

Rapid Communication | Open Access

Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy

Xun Qiu^{^a^,^b^,¹}, Hanzhi Xu^{^a^,^b^,¹}, Yawen Tan^{^a^,^b}, Jinying Li^{^c^,^d}, Zhoucheng Wang^{^a^,^b}, Zhengxing Lian^{^b}, Xuyong Wei^{^a^,^b}, Luyang Yu^{^c^,^d}, Kai Wang^{^e}(), Xiao Xu^{^f^,^g}

()

Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China

Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, Zhejiang 310006, China

Institute of Genetics and Regenerative Biology, College of Life Sciences, Hangzhou, Zhejiang 310058, China

Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China

Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, China

School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310059, China

Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China

Peer review under responsibility of Chongqing Medical University.

¹ These authors contributed equally to this work.

Show Author Information

References

Gao F, Qiu X, Wang K, et al. Targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments. Aging Dis. 2022;13(4):1196–1214.

Crossref Google Scholar

Wang B, Wang Y, Zhang J, et al. ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Arch Toxicol. 2023;97(6):1439–1451.

Crossref Google Scholar

Zhang Q, Lai D. Application of human amniotic epithelial cells in regenerative medicine: a systematic review. Stem Cell Res Ther. 2020;11(1):439.

Crossref Google Scholar

Qiu X, Xu H, Wang K, Gao F, Xu X, He H. P-21 activated kinases in liver disorders. Cancers. 2023;15(2):551.

Crossref Google Scholar

Mao Y, Han CY, Hao L, et al. p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: role of nuclear factor erythroid 2-related factor 2 phosphorylation. Hepatology. 2022;76(2):345–356.

Crossref Google Scholar

Genes & Diseases

Volume 12 Issue 2,
March 2025

Article number: 101343

DOI: 10.1016/j.gendis.2024.101343

Cite this article:

Qiu X, Xu H, Tan Y, et al. Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy. Genes & Diseases, 2025, 12(2): 101343. https://doi.org/10.1016/j.gendis.2024.101343