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Review Article | Open Access

Phenotype change of polarized microglia after intracerebral hemorrhage: Advances in research

Ran Tanga, Zhuyi Huangb, Heling Chuc( )
Nanjing Medical University, Nanjing 210000, China
Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai 200120, China
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
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Abstract

Spontaneous intracerebral hemorrhage (ICH) accounts for approximately 10–15% of all strokes with high rates of mortality and residual disability. Multiple studies have demonstrated that microglia-mediated neuroinflammation exerts a significant function on the secondary injury of ICH, which may cause severe brain damage or potential neurorestoration in different conditions. Microglia are the major phagocytes in central nervous system. In different time courses after ICH, microglia can be activated and polarized into two different states: classic M1-like phenotypes in the early stage and alternative M2-like phenotypes in long-term recovery. The mechanism of this phenotypic change is very complicated, including the influence of inflammatory mediators and microglia-astrocyte crosstalk. In this work, we encapsulate the M1-to-M2 microglial phenotype transition as well as its effects on post-ICH neuroinflammation, and describe potential therapeutic targets based on this feature.

Keywords

MicrogliaIntracerebral hemorrhageNeuroinflammation

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Brain Hemorrhages
Volume 1 Issue 3,
September 2020
Pages 161-165
DOI: 10.1016/j.hest.2020.08.001
Cite this article:
Tang R, Huang Z, Chu H. Phenotype change of polarized microglia after intracerebral hemorrhage: Advances in research. Brain Hemorrhages, 2020, 1(3): 161-165. https://doi.org/10.1016/j.hest.2020.08.001

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Received: 09 June 2020
Revised: 14 August 2020
Accepted: 19 August 2020
Published: 01 September 2020
© 2020 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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